| Investigation on the Maternal-Infantile Infection with Human Parvovirus B19 |
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| 引用本文： | 王净,窦骏,过志君,许桦,任慕兰,蒋黎. Investigation on the Maternal-Infantile Infection with Human Parvovirus B19[J]. 中华微生物学和免疫学杂志(英文版), 2004, 2(2): 111-114 |
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| 作者姓名： | 王净 窦骏 过志君 许桦 任慕兰 蒋黎 |
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| 作者单位： | Department of Obstetrics and Gynecology，Affiliated Zhongda Hospital，Southeast University，Nanjing 210009，China，Department of Pathogenic Biologics and Immunology，School of Basic Medical Science，Southeast University，Nanjing 210009，China，Department of Obstetrics and Gynecology，Affiliated Zhongda Hospital，Southeast University，Nanjing 210009，China，Department of Immunology，Affiliated Zhongda Hospital，Southeast University，Nanjing 210009，China，Department of Obstetrics and Gynecology，Affiliated Zhongda Hospital，Southeast University，Nanjing 210009，China，Department of Paediatrics，Affiliated Zhongda Hospital，Southeast University，Nanjing 210009，China |
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| 摘 要： | With the investigations on pregnant women and newbornsinfected withToxoplasma, rubella virus, cytomegalovirus,herpes simplex virus (TORCH), it was found that humanparvovirus B19 (B19 virus), which belongs to the familyParvoviridae and the genus Erythrovir…
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| 关 键 词： | 母婴传染 垂直传播 细小病毒 病毒感染 B19 |
Investigation on the Maternal-Infantile Infection with Human Parvovirus B19 |
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| Jing WANG,Jun DOU,Zhijun GUO,Hua XU,Mulan REN and Li JIANG. Investigation on the Maternal-Infantile Infection with Human Parvovirus B19[J]. Chinese Journal of Microbiology and Immunology, 2004, 2(2): 111-114 |
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| Authors: | Jing WANG Jun DOU Zhijun GUO Hua XU Mulan REN Li JIANG |
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| Affiliation: | [1]DepartmentofObstetricsandGynecology,AffihatedZhongdaHospital,SoutheastUniversity,Nanjing210009,China [2]DepartmentofPathogenicBiologicsandImmunology,SchoolofBasicMedicalScience,SoutheastUniversity,Nanjing210009,China [3]DepartmentofImmunology,AffiliatedZhongdaHospital,SoutheastUniversity,Nanjing210009,China |
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| Abstract: | To investigate the maternal-infantile infection with human parvovirus B19, the IgG and IgM antibodies against human parvovirus and the B19-DNA in serum and peripheral blood mononuclear cells (PBMC) of pregnant women as well as the serum IgM antibody against B19 and the B19-DNA in serum and cord blood nucleated cells (CBNC) of newborns were determined by ELISA and nested PCR respectively. It was found that the positive rate of the IgG antibody against human parvovirus B19 in sera of 92 pregnant women was 38.04% (35/92), and that of the IgM antibody in 720 pregnant women was 9.03% (65/720). However, the IgM antibody against human parvovirus B19 was negative in the cord blood sera of 95 newborns. As to the human parvovirus B19 DNA, none of 720 pregnant women and 95 newborns was proved to be positive in their sera. Nevertheless, the positive rate of the parvovirus B19 DNA in PBMC was 3.06% (3/98) in 98 pregnant women and 1.12% (1/89) in CBNC of 89 newborns. It is concluded that the history of infection with human parvovirus B19 exists in certain pregnant women with a small percentage of pregnant women infected with recent or acute infections of B19 virus. The detection rates of the B19 viral DNA in PBMC of pregnant women and CBNC of newborns were higher than those in sera, indicating that the risk for vertical transmission is very low. |
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| Keywords: | Human parvovirus B19 Maternal-infantile infection Peripheral blood mononuclear cells Cord blood nucleated cells Vertical transmission |
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