IL-12、IFN-γ与复发性流产的相关性研究

目的：测定复发性流产（RSA）患者血清IL-12、IFN-γ水平，探讨IL-12和IFN-γ与复发性流产发病的关系。方法：采用酶联免疫吸附法检测RSA患者30例(RSA组)， 血清IL-12、IFN-γ水平，并以正常早孕妇女25例 （NEP组）及健康未孕妇女25例（NNP组）作为两个对照组。结果：RSA患者血清IL-12、IFN-γ水平显著高于正常早孕妇女及正常未孕妇女（P<0.05），且两者水平呈正相关性（r=0.580,P<0.01），正常早孕妇女血清IL-12、IFN-γ水平低于未孕妇女但无统计学意义（P>0.05）。复发性流产患者流产次数与血清IL-12和IFN-γ水平差异无显著性（P>0.05）。结论：IL-12和IFN-γ在复发性流产发生机制中起一定的作用。

Correlation between levels of IL-12 and IFN-γ and recurrent spontaneous abortion

Objective: To explore the correlation between levels of interleukin-12(IL-12) and interferon-γ(IFN-γ) and recurrent spontaneous abortion (RSA). Methods: Thirty patients with RSA( the RSA group), twenty-five normal early pregnant women (the NEP group) and twenty five normal non-pregnant women( the NNP group) were enrolled in this study. The serum concentrations of IL-12 and IFN-γwere determined by enzyme-linked immunosorbant assay(ELISA). Results: Levels of IL-12 and IFN-γ were significantly higher in the RSA group than in the other groups(P<0.05) and there was a positive correlation between IL-12 and IFN-γ. Levels of IL-12 and IFN-γ were lower in the NEP group than in the NNP group, but there was no statistical difference(P>0.05). Conclusion： IL-12 and IFN-γ may play an important role in the occurrence of RSA.