| 空气中高浓度二氯乙烷对蚕豆根尖细胞遗传毒性研究 |
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| 引用本文： | 陈洋,周小敏,熊旭辉,谭广辉,张琼. 空气中高浓度二氯乙烷对蚕豆根尖细胞遗传毒性研究[J]. 临床军医杂志, 2012, 40(3): 526-528 |
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| 作者姓名： | 陈洋 周小敏 熊旭辉 谭广辉 张琼 |
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| 作者单位： | 广东省惠州市职业病防治院,广东 惠州,516000 |
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| 摘 要： | 目的探讨将蚕豆根尖微核检测系统(micronucleus,MCN)应用于空气污染物致突变性检测的可行性。方法以市售蚕豆为材料,在密闭容器中模拟室内空气的高浓度二氯乙烷污染,对蚕豆进行染毒。结果随着浓度的递增,平均微核率、染色体畸变率逐步上升,有丝分裂指数有下降趋势,表现出明显的剂量效应关系。结论在实验浓度下,1,2-二氯乙烷有对蚕豆根尖细胞产生遗传毒害效应。应用蚕豆根尖微核技术检测室内高浓度1,2-二氯乙烷污染物是可行的。
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| 关 键 词： | 蚕豆根尖 遗传毒性 微核 染色体畸变分析 工作场所空气污染 |
The genotoxicity of High-Dose Concentration in the Air on Vicia faba Root Tips Cells |
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| Chen Yang , Zhou Xiao-min , Xiong Xu-hui , Tan Guang-hui , Zhang Qiong. The genotoxicity of High-Dose Concentration in the Air on Vicia faba Root Tips Cells[J]. Clinical Journal of Medical Officer, 2012, 40(3): 526-528 |
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| Authors: | Chen Yang Zhou Xiao-min Xiong Xu-hui Tan Guang-hui Zhang Qiong |
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| Affiliation: | (Occupational Disease Prevention Hospital of Huizhou City,Huizhou Guangdong 516000,China) |
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| Abstract: | Objective To explore the feasibility of micronucleus test of Vicia faba root-tip cell in application of mutation detection caused by air pollutants.Methods This experiment takes available Vicia faba as research objects,which was poisoned by high concentration dichloroethane of simulated indoor air at airtight container.Results With the increasing of concentration,the descending trend of mitotic index and the escalation of average micronucleus rate and chromosome aberration rate had been observed,which showed a conspicuous dose-response relationship.Conclusion Genetic toxic effects of Vicia faba root-tip cell caused by dichloroethane are unquestionable under all experiment concentration.Furthermore,it is possible that the using of micronucleus test in Vicia faba Linn root-tip cell for high concentration dichloroethane of indoor air. |
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| Keywords: | Vicia faba root-tip cell genotoxicity micronucleus chromosomal aberrations workplace air pollutants |
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