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| Effects of Potassium Aspartate and Magnesium on Ventricular Arrhythmia in Ischemia-reperfusion Rabbit Heart | |
| 引用本文： | 卜军,张存泰,全小庆,赵国安,吕家高,李波,白融,刘念,阮燕菲,何奔. Effects of Potassium Aspartate and Magnesium on Ventricular Arrhythmia in Ischemia-reperfusion Rabbit Heart[J]. 华中科技大学学报(医学英德文版), 2008, 28(5): 517-519. DOI: 10.1007/s11596-008-0506-x |
| 作者姓名： | 卜军 张存泰 全小庆 赵国安 吕家高 李波 白融 刘念 阮燕菲 何奔 |
| 作者单位： | Department of Cardiology，Renji Hospital，Shanghai Jiaotong University School of Medicine，Department of Cardiology，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology，Department of Cardiology，the Third Affiliated Hospital，Xinxiang Medical College |
| 摘 要： | The aim of this study was to determine if the potassium aspartate and magnesium (PAM) prevent reperfusion-induced ventricular arrhythmias (RIVA) in ischemia-reperfusion (IR) rabbit heart. Thirty rabbits were randomly divided into control, ischemia and PAM groups. Arterially-perfused rabbit left ventricular preparations were made, and transmural ECG as well as action potentials from both endocardium and epicardium were simultaneously recorded in the whole process of all experiments. In control group rabbit ventricular wedge preparations were continuously perfused with Tyrode's solution, and in ischemia group and PAM groups the perfusion of Tyrode's solution was stopped for 30 min. Then the ischemia group was reperfused with Tyrode's solution and the PAM group with Tyrode's solution containing 2.42 mg/L PAM, respectively. ECG, QT interval, transmural repolarization dispersion (TDR) and action potentials from epicardium and endocardium were simultaneously recorded, and the RIVA of the wedge preparation was observed. Compared with control group, TDR and incidence of RIVA were significantly increased in ischemia group (P<0.05). The incidence of RIVA in control, ischemia and PAM group was 0/10, 9/10 and 1/10, respectively. Compared with ischemia group, TDR and incidence of RIVA were significantly reduced in PAM group (P<0.05). Potassium aspartate and magnesium significantly reduce TDR and prevent ventricular arrhythmia in ischemic rabbit heart. |
| 关 键 词： | 缺血性室性心律失常 缺血再灌注 门冬氨酸钾 家兔 聚丙烯酰胺 镁 动作电位 PAM |
Effects of potassium aspartate and magnesium on ventricular arrhythmia in ischemia-reperfusion rabbit heart |
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| Jun Pu,Cuntai Zhang,Xiaoqing Quan,Guoan Zhao,Jiagao Lv,Bo Li,Rong Bai,Nian Liu,Yanfei Ruan,Ben He. Effects of potassium aspartate and magnesium on ventricular arrhythmia in ischemia-reperfusion rabbit heart[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2008, 28(5): 517-519. DOI: 10.1007/s11596-008-0506-x | |
| Authors: | Jun Pu Cuntai Zhang Xiaoqing Quan Guoan Zhao Jiagao Lv Bo Li Rong Bai Nian Liu Yanfei Ruan Ben He |
| Affiliation: | 1. Department of Cardiology, Renji Hospital, Shanghai diaotong University School of Medicine, Shanghai 200001, China;Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China 2. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China 3. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China;Department of Cardiology, the Third Affiliated Hospital, Xirixiang Medical College, Xinxiang 453003, China 4. Department of Cardiology, Renji Hospital, Shanghai diaotong University School of Medicine, Shanghai 200001, China |
| Abstract: | The aim of this study was to determine if the potassium aspartate and magnesium (PAM) prevent reperfusion-induced ventricular arrhythmias (RIVA) in ischemia-reperfusion (IR) rabbit heart. Thirty rabbits were randomly divided into control, ischemia and PAM groups. Arterially-perfused rabbit left ventricular preparations were made, and transmural ECG as well as action potentials from both endocardium and epicardium were simultaneously recorded in the whole process of all experiments. In control group rabbit ventricular wedge preparations were continuously perfused with Tyrode's solution, and in ischemia group and PAM groups the perfusion of Tyrode's solution was stopped for 30 min. Then the ischemia group was reperfused with Tyrode's solution and the PAM group with Tyrode's solution containing 2.42 mg/L PAM, respectively. ECG, QT interval, transmural repolarization dispersion (TDR) and action potentials from epicardium and endocardium were simultaneously recorded, and the RIVA of the wedge preparation was observed. Compared with control group, TDR and incidence of RIVA were significantly increased in ischemia group (P<0.05). The incidence of RIVA in control, ischemia and PAM group was 0/10, 9/10 and 1/10, respectively. Compared with ischemia group, TDR and incidence of RIVA were significantly reduced in PAM group (P<0.05). Potassium aspartate and magnesium significantly reduce TDR and prevent ventricular arrhythmia in ischemic rabbit heart. |
| Keywords: | ischemia-reperfusion ventricular arrhythmia potassium aspartate and magnesium |
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