Evalution of Flunisolide Nasal Solution in the Symptomatic Treatment of Perennial Rhinitis

The effectiveness of a topical steroid, flunisolide, was evaluated in patients with perennial rhinitis. Thirty-four patients went through a double-blind cross-over study. comparing flunisolide 200 μg per day with placebo. The symptoms were assessed over two treatment periods each of 4 weeks, with a 2 weeks washout period in between. There was a statistically significant difference on favour of flunisolide. About half of the patients complained of mild initial irritation from both active drug and placebo.