| 蝎毒抗癌多肽对人肝癌细胞株的作用 |
| |
| 引用本文： | 魏玲,孔天翰,董伟华. 蝎毒抗癌多肽对人肝癌细胞株的作用[J]. 肿瘤防治研究, 2002, 29(1): 9-11 |
| |
| 作者姓名： | 魏玲 孔天翰 董伟华 |
| |
| 作者单位： | 1. 山东省肿瘤防治研究中心实验室,济南,250117
2. 河南医科大学生物毒素中心 |
| |
| 基金项目： | 河南省“九五”科技攻关项目（951200102） |
| |
| 摘 要： | 目的 观察蝎毒抗癌多肽（ＡＰＢＭＶ）对人肝癌细胞ＳＭＭＣ－７７２１的作用。方法ＭＴＴ法、生长抑制实验和集落形成实验。结果 ＡＰＢＭＶ对 ＳＭＭＣ－７７２１细胞具较强毒性作用，ＩＣ５０为１１．３３μｇ／ｍｌ；ＡＰＢＭＶ可显著抑制细胞生长，剂量与时间效应关系明显。结论ＡＰＢＭＶ是东亚钳蝎蝎毒中有效低毒的抗肿瘤成分，对肝癌细胞有一定的毒性作用。
|
| 关 键 词： | 蝎毒 肝癌 细胞株 多肽 |
| 文章编号： | 1000-8578(2002)01-0009-03 |
| 收稿时间： | 2001-03-02 |
| 修稿时间： | 2001-05-28 |
The effect of APBMV on human hepotoma cell line |
| |
| WEI Ling,KONG Tian-han,DONG Wei-hua. The effect of APBMV on human hepotoma cell line[J]. Cancer Research on Prevention and Treatment, 2002, 29(1): 9-11 |
| |
| Authors: | WEI Ling KONG Tian-han DONG Wei-hua |
| |
| Affiliation: | Shandong Tumor Hospital &; Institute; Ji nan 250117; China |
| |
| Abstract: | Objective To obserne the effect of antineoplastic polypeptide from Buthus martensii venom (APBMV) on the human heptoma cells SMMC-7721. Methods Using the MTT colorimetric method, the growth-inhibiting test and the colony-formation inhibiting assay. Results The results revealed that APBMV had obvious cytotoxicity on SMMC-7721,1C50 was 11. 33μg/ml;APBMV could obviously inhibit the cellu- lar growth. There were obvious dose-response and timeresponse relationship. The IC50 we... |
| |
| Keywords: | Scorpion venom Liver neoplasm Cell line Polypeptide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《肿瘤防治研究》浏览原始摘要信息 |
|
点击此处可从《肿瘤防治研究》下载免费的PDF全文 |
