急性肾功能衰竭患者测定血清A1b、IgG和血脂水平诊断早期肾功能损伤的临床研究

目的探讨急性肾功能衰竭（ARF）患者测定血清A1b、IgG和血脂水平诊断早期肾功能损伤的临床意义。方法用免疫比浊法和生化法测定了86例ARF患者和42名正常对照组血清A1b、IgG和血脂（TC、TG、HDL—C、LDL—C、APOA和APOB）水平，并进行了对比性分析。结果ARF患者血清A1b和IgG水平分别为25．21±7．02mg／L和16．43±4．25g／L较正常对照组（42．36±4．58mg／L，24．71±5．01g／L）明显降低（P〈0．05，P〈0．01）。在血脂分析中，ARF患者血清TC、TG、LDL—C和APOB水平较正常对照组明显增高或非常明显增高（P〈0．05～0．01），而血清HDL-C和APOA水平两组无明显差异（P均〉0．05）。结论ARF患者血清A1b和IgG水平明显降低以及血脂代谢紊乱是诊断早期肾功能损伤的有效指标。

Clinical Study of Diagnosis of Early Renal Impairment through Determining Serum A1b,IgG and Blood Lipid Levels in Patients with Acute Renal Failure

Objective To explore the diagnosis of early renal impairment through determining serum A1b,IgG and blood lipid levels in patients with acute renal failure（ARF）.Methods The immunoturbidimetry assay and biochemistry method were used to determine serum A1b,IgG and blood lipid （including TC,TG,HDL-C,LDL- C,APOA and APOB） levels in 86 patients with ARF and 42 controls.Their two sections were done compared analysis.Results The serum A1b and IgG levels in 86 patients with ARF were 25.21± 7.02mg/L and 16.43 ± 4.25g/ L respectively,were significantly lower than those in 42 controls（42.36±4.58mg/L and 24.71 ±5.01g/Lp 〈 0.05 and P 〈 0.01）.In blood lipid analysis,the Serum TC,TG,LDL-C and APOB levels were significantly higher than those in 42 controls（P 〈 0.05 - 0.01）,but the serum HDL-C and APOA levels were not significantly different in two sections（P all 〉 0.05）.Conclusions The levels of serum A1b and IgG significantly decreased and blood lipid abnormal metabolism were helpful indexes for early diagnosis ARF.