3种材质输液容器对盐酸博来霉素A2和B2的吸附性考察

目的:考察非聚氯乙烯(PVC)多层共挤膜输液袋、聚丙烯(PP)输液瓶和玻璃瓶3种材质输液容器对盐酸博来霉素的吸附性。方法:取相同量的盐酸博来霉素加入3种包装材质的2种输液(5%葡萄糖注射液和5%葡萄糖氯化钠注射液)中,混合均匀后分别于0、6、24、48h时取样,采用高效液相色谱法测定药物浓度,与0h时浓度相比计算相对百分含量。结果:48h时,溶媒分别为5%葡萄糖注射液和5%葡萄糖氯化钠注射液时,在PP输液瓶中,盐酸博来霉素A2、B2相对百分含量分别为90.81%、89.56%和55.65%、82.4%;而在另2种材质包装的2种溶媒中,盐酸博来霉素A2、B2相对百分含量均大于95%。结论:3种材质中,以PP输液瓶对盐酸博来霉素吸附性最强,尤其是在以5%葡萄糖氯化钠注射液为溶媒时;临床使用该药时应避免选用该材质输液瓶。

Study on Adsorbability of Bleomycin Hydrochloride A2 and B2 in 3 Different Kinds of Intravenous Solution Containers

OBJECTIVE:To investigate the adsorbability of non-polyvinly chloride(NPVC) infusion bags,polypropylene(PP) infusion bags and glass bottles to bleomycin hydrochloride,respectively.METHODS:Bleomycin hydrochloride was separately added into above infusion bags or bottles containing 5% Glucose injection(GS) or 5% Glucose sodium chloride injection(GNS).Samples of drug solutions were collected at 0,6,24,48 hours and analyzed by HPLC methods.Relevant percentage content was calculated,compared with concentration at 0 h.RESULTS:At 48 h,solvent were 5% GS and 5% GNS,and relevant percentage contents of bleomycin hydrochloride A2 and B2 in PP bottles were 90.81%,89.56% and 55.65%,82.4%.Relevant percentage contents of bleomycin hydrochloride A2 and B2 in other 2 kinds of container were all more than 95%.CONCLUSION:Among 3 kinds of materials,PP infusion bottle shows the strongest adsorbability,especially for 5% GNS as solvent.PP should not be used for bleomycin hydrochloride.