血清超敏C反应蛋白与脑梗塞不同中医证型的相关性研究

目的:观察脑梗塞中医各证型与超敏C反应蛋白的关系,并观察不同证型患者神经系统缺损程度,并进行相关性分析,为脑梗塞在临床上诊断及中医分型找到相关依据。方法:将82例脑梗塞患者进行中医辨证分型,检测血清hs-CRP,同时测血清甘油三酯(TG),总胆固醇(TC)水平及高密度脂蛋白(HDL-C)含量,计算TC/HDL值及评价神经系统缺损程度,分析其与中医各证型的关系。结果:风痰瘀阻型、气虚血瘀型,hs-CRP及神经系统缺损程度明显,与阴虚风动型有显著性差异(P<0.05),3种证型TC、TG及TC/HDL值无显著差异(P>0.05);各证型中hs-CRP与TG,TC、TC/HDL值呈正相关。hs-CRP水平与脑梗塞患者神经系统缺损程度相关(P<0.05)。结论:hs-CRP增高是脑梗死痰证、血瘀证的一个重要客观指标,hs-CRP水平升高可能可作为病情评估的指标之一。

Study of Relation of Serum Supersensitivity C Reactive Protein and Different Syndromes of Cerebral Infarction

Objectives: To observe the relation of serum supersensitivity C reactive protein and different syndromes of cerebral infarction,and the degree of nervous system defect of different syndromes of cerebral infarction,and to analyse the relations.Offer the gist of clinical diagnosis and syndrome differentiation of TCM of cerebral infarction.Methods: As for 82cases of cerebral infarction,the different syndromes were differed,serum hs-CRP,serum TG,TC and HDL-C were detected.The value of TC/HDL was calculated,and the degree of nervous system defect was evaluated.The relation of different syndromes of TCM was analysed.Results: The hs-CRP is manifest abnormality and the degree of nervous system defect are manifest in the patients with wind-phlegm stasis,qi deficiency with blood stasis,and have significant deviation with those in patients with yin deficiency and liver wind.The values of TC,TG and TC/HDL have no significant deviation in the three syndromes.The value of hs-CRP has positive correlation with that of TG,TC and TC/HDL.The value of hs-CRP has correlation with the degree of patients with nervous system defect.Conclusions: The rise of the value of hs-CRP is the important index of phlegm syndrome,blood stasis of cerebral infarction.The rise of the value of hs-CRP maybe become one of the index of appraisal of patient's condition.