传染性单核细胞增多症患儿病原体的分布及肝酶的变化

目的:观察传染性单核细胞增多症(IM)患儿病原体分布情况及肝酶的变化。方法:分析170例初诊IM患儿EB病毒和TORCH中IgM抗体阳性分布情况及血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)的水平。结果:170例IM患儿,9例未检出病原体IgM抗体,30例检出1种病原体IgM抗体,131例检出2种或2种以上病原体IgM抗体。IM患儿血清ALT、AST升高,B、C、D、E组明显高于A组(P<0.05),B、C、D和E组之间无明显差异(P>0.05)。结论:IM可由多种病原体感染引起,以混合感染为主,尤其是EB病毒与巨细胞病毒、单纯疱疹病毒的混合感染。病原体IgM抗体阳性的IM患儿血清肝酶明显高于病原体IgM抗体阴性者,但与病原体IgM抗体阳性种类的多少无关。

Distribution of pathogen and change of hepatase in childhood-onset infectious mononucleosis

Objective:To observe the distribution of pathogen and change of hepatase in childhood-onset infectious mononucleosis(IM).Methods:Distribution of IgM antibodies,levels of ALT and AST in EB virus and TORCH of 170 IM patients were analyzed.Results:In all of the 170 patients,9 of them were not found IgM antibody,30 of them had one kind of IgM antibodies,131 patients had two or more kinds of IgM antibodies.The levels of ALT and AST were significantly higher in IM patients.In group B,C,D and E,the levels of ALT and AST were significantly higher than those in group A.But there was no significant difference between group B,C,D and group E.Conclusion:IM can be caused by many pathogens,especially mixed infection of EB virus and cytomegalovirus(CMV) or herpes simple virus(HSV).Level of hepatase in IM patients with IgM antibody positive was higher than that in those negative cases,which had no correlation to the types of IgM antibodies.