艾司洛尔对甲状腺手术中丙泊酚麻醉用量的影响

目的 探讨艾司洛尔对全麻丙泊酚用量的影响.方法 选取拟全麻下行甲状腺叶切除术患者40例,随机分为艾司洛尔组(E组)和对照组(C组)各20例.E组麻醉诱导前30 min时单次静注艾司洛尔0.5mg·kg-1,随后以50μg·kg-1·min-1的速度维持至手术结束:C组以等量生理盐水代替.记录血压、心率和脑电双频指数(BIS)值,以及麻醉时间、手术时间、苏醒时间及丙泊酚的诱导和维持量.结果 E组和C组比较,丙泊酚诱导用量较少而苏醒较快(P＜0.05).而两组丙泊酚维持用量无统计学差异.气管插管后E组BIS和心率较C组为低(P＜0.01).气管拔管时舒张压和气管拔管后5min的心率两组比较有显著差异.结论 静注艾司洛尔可降低丙泊酚诱导用量、缩短麻醉苏醒时间、减轻气管插管前后的BIS和心率波动,对丙泊酚维持用量没有明显影响.

Effect of esmolol on propofol dose requirement for anesthesia in thyroidectomy

OBJECTIVE: To observe the effect of esmolol application before and during operation on propofol dose required for anesthesia induction and maintenance. METHODS: Forty patients (ASA physical status I or II) undergoing general anesthesia for thyroidectomy were randomized equally into esmolol and control groups. Patients in esmolol group received a loading dose of esmolol at 0.5 mg/kg in 30 ml normal saline over a period of 5 min followed by an intravenous infusion of esmolol at 50 microg.kg(-1).min(-1) until the end of surgery, while patients in the control group were given normal saline in the same manner, in addition to anesthesia with protofol. Perioperative hemodynamic parameters and BIS were measured, and the duration of anesthesia, operation and recovery time from anesthesia were recorded. RESULTS: There were significant differences between the two groups in propofol dose required for anesthesia induction and recovery time from anesthesia, but not in maintenance propofol dose. Patients in esmolol group had significantly lower HR and BIS during tracheal intubation than those in the control group , and no significant differences were found in HR, BP and BIS during operation between the two groups. The hemodynamic parameters during extubation showed less fluctuation in esmolol group. CONCLUSION: Perioperative esmolol administration during anesthesia reduces propofol dose required for anesthesia induction and recovery time from anesthesia, and decreases HR and BIS variation during tracheal intubation and hemodynamic response during extubation without affecting the maintenance propofol dose.