Pathophysiology of interstitial lung disease |
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| Authors: | Duperron Florence Velea Valeria Ioos Vincent Brauner Michel Lamberto Christine Valeyre Dominique |
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| Affiliation: | 1. Service de Pneumologie, Hôpital Avicenne, 125, route de Stalingrad, 93009 Bobigny, et UFR SMBH, Université Paris 13, Bobigny;2. Service de Radiologie, Hôpital Avicenne, 125, route de Stalingrad, 93009 Bobigny, et UFR SMBH, Université Paris 13, Bobigny;3. Service d’Explorations Fonctionnelles, Hôpital Avicenne, 125, route de Stalingrad, 93009 Bobigny, et UFR SMBH, Université Paris 13, Bobigny;1. Service de pneumologie, hôpital Tenon, université P&M Curie, AP–HP, 4, rue de la Chine, 75970 Paris, France;2. Service de maladies infectieuses et tropicales, hôpital Bichat-Claude-Bernard, université Denis-Diderot, AP–HP, Paris, France;1. Service d’allergologie pédiatrique, hôpital Trousseau, Sorbonne Universités, UPMC Univ Paris 06, faculté de médecine Pierre-et-Marie-Curie, Inserm UMR_S1136, 26, avenue du Dr-Netter, 7012;2. Service de pneumologie, allergologie et CRCM pédiatrique, faculté Paris Diderot, Inserm UMR S 976, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris;1. Centre for Heart Lung Innovation, St. Paul’s Hospital, 166-1081 Burrard Street, Vancouver, British Columbia V6T 1Y6, Canada;2. Department of Physical Therapy, Faculty of Medicine, University of British Columbia, 212 Friedman Building, 2177 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada;3. Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Gordon and Leslie Diamond Health Care Centre, 7th Floor, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada |
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| Abstract: | Chronic interstitial lung disease (ILD) groups a number of diseases with the common feature of radiological pulmonary infiltration, typical functional syndrome, and diffuse involvement of the deep pulmonary parenchyma identified histologically. Correlations between histological and radiological findings have enabled progress in both fields, leading to better interpretation of the radiological findings and optimizing the etiological diagnosis. Besides the signs themselves, their distribution in relation to the normal lung structures is highly contributive. Function tests can be used to quantify the impact on the respiratory system and assess the effect of treatment. Evidence-based criteria will progressively replace the consensual criteria enabling more effective evaluation of treatment in difficult pathological conditions such as idiopathic pulmonary fibrosis. |
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