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| 药物作用新靶点：白细胞介素17及其受体 | |
| 引用本文： | 孙创斌,胡晋红,朱全刚,刘继勇,刘艳霞. 药物作用新靶点：白细胞介素17及其受体[J]. 国际药学研究杂志, 2008, 35(3): 169-172 |
| 作者姓名： | 孙创斌 胡晋红 朱全刚 刘继勇 刘艳霞 |
| 作者单位： | 第二军医大学长海医院药学部,上海,200433 |
| 摘 要： | 白细胞介素17（IL-17）是近年来新发现Th17细胞分泌的致炎细胞因子，在机体炎症及自身免疫性疾病中发挥重要作用。IL-17与其受体结合后通过信号转导而发挥作用。IL-17R-Ig融合蛋白是IL-17受体的有效抑制剂。本文综述IL-17及其受体的生物学效应、信号转导途径、与疾病的关系及药物的影响等，为IL-17及其受体作为药物作用的新靶点提供新思路。 |
| 关 键 词： | 白细胞介素17； 受体 白细胞介素17； 自身免疫疾病； 炎症 |
| 收稿时间： | 2007-10-29 |
New targets for drugs: interleukin 17 and its receptors |
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| SUN Chuang-bin,HU Jin-hong,ZHU Quan-gang,LIU Ji-yong,LIU Yan-xia. New targets for drugs: interleukin 17 and its receptors[J]. Foreign Medical Sciences(Section of Pharmarcy), 2008, 35(3): 169-172 | |
| Authors: | SUN Chuang-bin HU Jin-hong ZHU Quan-gang LIU Ji-yong LIU Yan-xia |
| Affiliation: | （Department of Pharmacy，Changhai Hospital，the Second Military Medical University，Shanghai 200433，China） |
| Abstract: | Interleukin 17(IL-17) is a member of potent proinflammatory cytokines secreted by Th17 cell subset. It plays a pathological role in inflammatory and autoimmune diseases for its specific biological effects. IL-17 binds its receptor to transduce signals and produce response. The effective inhibitor of IL-17 receptor-Ig fusion protein showed good therapeutic effects in experiments. This paper reviews the biological effect，signal transduction pathway, associated diseases of IL-17 and its receptors, etc, and provides new ways for IL-17 and its receptor as new drug targets. |
| Keywords: | interleukin 17； receptor interleukin 17； autoimmune disease inflammation |
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