Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers |
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| Authors: | Rosalyn D Blumenthal Evelyn Leon Hans J Hansen David M Goldenberg |
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| Affiliation: | (1) Garden State Cancer Center, Center for Molecular Medicine and Immunology, 07109 Belleville, NJ, USA (RDB, EL, DMG);(2) Immunomedics, Inc., Morris Plains, NJ, 07950, USA (HJH) |
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| Abstract: | Background Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic
antigen, CEA), and antibodies to both can affect tumor cell growth in vitro and in vivo. Here, we compare both antigens as
a function of histological phenotype in breast, pancreatic, lung, ovarian, and prostatic cancers, including patient-matched
normal, primary tumor, and metastatic breast and colonic cancer specimens. |
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