| 抗肿瘤药物的治疗监测 |
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| 引用本文： | 钱新华,张能芳,高凌.抗肿瘤药物的治疗监测[J].药学与临床研究,2003,11(6):36-39. |
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| 作者姓名： | 钱新华 张能芳 高凌 |
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| 作者单位： | 江苏省肿瘤防治研究所，南京210009 |
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| 摘 要： | 大多数抗肿瘤药具有治疗指数低、毒性大、药动学参数个体差异大的特性，临床需进行治疗药物监测，以达到个体化给药。但治疗药物监测最基本的条件——量效关系，对大多数肿瘤药而言只是量毒关系，基于提高临床疗效的治疗药物监测除少数药物外目前尚不可行。
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| 关 键 词： | 抗肿瘤药 治疗药物监测 个体化给药 |
| 收稿时间： | 2003/4/23 0:00:00 |
Therapeutic Drug Monitor for Anticancer Drug |
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| Qian xinhu,Zhang nengfang and Gao ling.Therapeutic Drug Monitor for Anticancer Drug[J].Pharmacertical and Clinical Research,2003,11(6):36-39. |
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| Authors: | Qian xinhu Zhang nengfang and Gao ling |
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| Abstract: | Most anticancer drugs have the feature of l ow ther apeutic index,high toxicity and wide inter-patient variability of pharmacokine ti c parameters,therapeutic drug monitor (TDM) is needed in individual chemothera p y of cancer. But the basic element,dose-efficacy relationship. For TDM of ant ic ancer drug is dose-toxicity relationship only,therefore TDM for improving cli nical efficacy is not practicable except for few anticancer drug. |
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| Keywords: | Anticancer drug TDM Individual chemotherapy |
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