| 驻极体促进水杨酸甲酯的体外透皮释药 |
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| 引用本文： | 崔黎丽,宋诚荣等. 驻极体促进水杨酸甲酯的体外透皮释药[J]. 第二军医大学学报, 2001, 22(5): 415-417 |
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| 作者姓名： | 崔黎丽 宋诚荣等 |
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| 作者单位： | [1]第二军医大学药学院无机化学教研室,上海200433 [2]基础医学院数理教研室 |
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| 基金项目： | 国家自然科学基金资助项目 ( 3 9770 880 ) |
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| 摘 要： | 目的：研究负极性驻极体对水杨酸甲酯透皮扩散的影响。方法：用改进的Franz扩散池和高效液相色谱（HPLC）法测定水杨酸甲酯离体小鼠皮肤的通透流量。结果：与对照组相比,负极性驻极体组水杨酸甲酯的皮肤通透流量增加1．55倍,且有显性差异（P＜0．05）。结论：负极性驻极体对水杨酸甲酯的透皮扩散有促进作用。
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| 关 键 词： | 驻极体 透皮扩散 水杨酸甲酯 通透流量 |
| 文章编号： | 0258-879X(2001)05-0415-03 |
| 修稿时间： | 2000-10-25 |
Enhancing effect of electrets on transdermal delivery of methyl salicylate in vitro |
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| CUI Li Li ,JIANG Jian ,ZHANG Li ,SONG Cheng Rong ,ZHAO Wei Quan ,LIN Jin Ming. Enhancing effect of electrets on transdermal delivery of methyl salicylate in vitro[J]. Former Academic Journal of Second Military Medical University, 2001, 22(5): 415-417 |
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| Authors: | CUI Li Li JIANG Jian ZHANG Li SONG Cheng Rong ZHAO Wei Quan LIN Jin Ming |
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| Affiliation: | CUI Li Li 1,JIANG Jian 2,ZHANG Li 1,SONG Cheng Rong 2,ZHAO Wei Quan 1,LIN Jin Ming 1 |
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| Abstract: | Objective: To study the influence of negative electrets on transcutaneous permeation of methyl salicylate through rat skin in vitro . Methods: The penetration flux of methyl salicylate through rat skin in vitro was performed by high performance liquid chromatograph (HPLC) and improved Franz diffusion cells. Results: The penetration flux of negative electrets group was 1.55 times higher than that of control group ( P <0.05). Conclusion: Negative electrets can enhance methyl salicylate delivery through rat skin in vitro . |
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| Keywords: | electret transdermal delivery methyl salicylate penetration flux |
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