凯西莱联合双环醇治疗非酒精性脂肪性肝炎的临床研究

目的探讨凯西莱联合双环醇片（白赛诺）治疗非酒精性脂肪性肝炎（NASH）的疗效。方法将60例NASH患者随机分为观察组与对照组，观察组30例给予凯西莱联合双环醇治疗，对照组30例单纯用凯西莱治疗。疗程均为24周。治疗前后测定两组患者ALT、TBiL、TC、TG及肝／脾CT比值。结果两组患者治疗后ALT、TBiL、TC、TG均下降，肝／脾cT比值均升高，观察组比对照组改善更明显，差异均有统计学意义（P均〈0．01）。结论凯西莱联合双环醇治疗NASH效果良好，值得临床应用。

Clinical study of tiopronin combined with bicyclol tablets in treatment of nonalcoholic steatohepatitis

Objective To study the clinical efficacy of tiopronin combined with bicyclol tablets in treatment of nonalcoholic steatohepatitis.Methods 100 patients with nonalcoholic steatohepatitis were randomly divided into experimental group treated with tiopronin combining with bicyclol tablets(n=50)and control group treated with only tiopronin(n=50) for consecutive 24 weeks.The level of serum ALT,TBiL,TC,TG and liver/spleen CT index were measured before and after treatment,respectively.Results The levels of serum ALT,TBiL,TC,TG in experiment group were decreased obviously after treatment.Meanwhile,liver/spleen CT indexes were increased obviously after treatment.There were a significant difference between the two groups(P<0.01).Conclusion Treatment with tiopronin combined with bicyclol tablets was an effective remedy for treating nonalcoholic steatohepatitis.It was worth of clinical application.