急性胰腺炎患者血浆降钙素原的变化及其意义

目的探讨血浆降钙素原（PCT）水平对急性胰腺炎（AP）患者预后的预测价值。方法将入选的122例急性胰腺炎患者，根据Ranson评分标准分为轻型胰腺炎组（68例）和重型胰腺炎组（54例），比较两组患者白细胞计数、中性粒细胞比值、血浆淀粉酶、脂肪酶、C反应蛋白（CRP）以及PCT水平。腹部CT检查评估两组患者CT严重指数（C鸭I），评估CTSI和血浆PCT水平的相关性。结果（1）与轻型急性胰腺炎患者相比，重型组患者白细胞总数、中性粒细胞比值、血浆淀粉酶、脂肪酶、CRP以及PCT均明显升高，差异具有统计学意义（P〈0．05）；（2）Spearman相关分析提示CTSl分级与血浆PCT水平呈正相关（r=0．886，P〈0．05）。结论检测急性胰腺炎患者血浆PCT水平有利于对患者预后的评估。

Predictive value of serum level of procalcitonin on the prognosis of patients with acute pancreatitis

Objective To investigate the predictive value of serum level of procalcitonin(PCT) on the prognosis of patients with acute pancreatitis.Methods 122 patients defined as acute pancreatitis were enrolled and assigned into mild(68 patients) and severe(54 patients) groups according to the Ranson criterion.The white blood cell count,ratio of neutrophil,and serum levels of amylase,lipase,C-reactive protein(CRP) and PCT were compared between the two groups.CT scan was applied to evaluate the CT severe index(CTSI) of the two groups and the relationship of CTSI with serum level of PCT were analyzed.Results(1) Compared to the mild group,total number of white blood cell,ratio of neutrophil,and serum levels of amylase,lipase,CRP and PCT were significantly higher in severe group(P<0.05).(2) Exudation,abscess and necrosis of pancreas were worse in severe group than mild group as indicated by the CTSI,and CTSI was positive correlation with serum level of PCT as indicated by Spearman rank correlation analysis(r=0.886,P<0.05).Conclusion It is beneficial to predict the prognosis of patients with acute pancreatitis by the detection of serum level of PCT.