Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma |
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| Authors: | Jian?Yu,Hongyu?Zhang,Jun?Gu,Song?Lin,Junhua?Li,Wei?Lu,Yifei?Wang,Jingde?Zhu mailto:zhujingde@yahoo.com" title=" zhujingde@yahoo.com" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | (1) Cancer Epigenetics and Gene Therapy, State-Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200/25, Xie-Tu Road, Shanghai, 200032, China;(2) Department of Neurosurgery, Tiantan Hospital of Capital University of Medical Sciences, Beijing Neurosurgical Institute, Beijing, 100050, China;(3) Department of Mathematics, Shanghai University, No. 99, Shangda Road, Shanghai, 200436, P. R. China |
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| Abstract: | ![]()
Background Astrocytoma is a common aggressive intracranial tumor and presents a formidable challenge in the clinic. Association of altered DNA methylation patterns of the promoter CpG islands with the expression profile of cancer-related genes, has been found in many human tumors. Therefore, DNA methylation status as such may serve as an epigenetic biomarker for both diagnosis and prognosis of human tumors, including astrocytoma. |
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