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| Eotaxin-3基因多态性与变应性哮喘相关研究 | |
| 引用本文： | 高贵民 吴健民 崔天盆 张继成. Eotaxin-3基因多态性与变应性哮喘相关研究[J]. 临床检验杂志, 2006, 24(2): 128-130 |
| 作者姓名： | 高贵民 吴健民 崔天盆 张继成 |
| 作者单位： | 华中科技大学同济医学院附属协和医院检验科,武汉,430022;华中科技大学同济医学院附属协和医院检验科,武汉,430022;华中科技大学同济医学院附属协和医院检验科,武汉,430022;华中科技大学同济医学院附属协和医院检验科,武汉,430022 |
| 摘 要： | 目的研究湖北地区汉族成人 2497T/G单核苷酸多态性与哮喘易感性、嗜酸性粒细胞计数以及血浆总IgE水平相关性。方法用聚合酶链反应-单链构象多态性-4引物聚合酶链反应的方法进行分析。结果eotaxin-3 2497位G等位基因的频率在哮喘组与对照组、哮喘组中TT、TG基因型的IgE浓度及EOS数量差异有显著性,P值分别为0.011,0.021和0.029。结论eotaxin-3 2497T/G多态性与哮喘易感性、EOS数量及IgE水平相关。 |
| 关 键 词： | 嗜酸性粒细胞趋化因子-3 基因多态性 变应性哮喘 |
| 文章编号： | 1001-764X(2006)02-0128-03 |
| 收稿时间： | 2005-06-13 |
| 修稿时间： | 2006-01-13 |
Association between polymorphisms of eotaxin-3 + 2497T/G and asthma |
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| GAO Guimin,WU Jianmin,CUI Tianpen,ZHANG Jicheng.. Association between polymorphisms of eotaxin-3 + 2497T/G and asthma[J]. Chinese Journal of Clinical Laboratory Science, 2006, 24(2): 128-130 | |
| Authors: | GAO Guimin WU Jianmin CUI Tianpen ZHANG Jicheng. |
| Affiliation: | Department of Medical Laboratory, Union hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430022, China |
| Abstract: | Objective To study the single nucleotide polymorphisms of 2497 in eotaxin-3 and its association with asthma susceptibility,total IgE level and eosinophil count in adult population of the Han nationality from Hubei province of China.Methods Polymerase chain reaction-single strand conformation polymorphism and tetra-primer polymerase chain reaction were used to identify the single nucleotide polymorphisms.Results The frequencies of eotaxin-3 2497 G allele between asthma group and control group were significantly different(P value:0.011).The total levels of plasma IgE and peripheral eosinophil counts between TT and TG genotypes in asthma group were significantly different and the P values were 0.021 and 0.029 respectively.Conclusion Polymorphism of eotaxin-3 2497 is associated with the susceptibility of asthma,peripheral eosinophil counts and total levels of plasma IgE. |
| Keywords: | eotaxin-3 single nucleotide polymorphism asthma |
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