| Regulation of Astroglia on Synaptic Plasticity in the CA1 Region of Rat Hippocampus |
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| 作者姓名： | 谭来勋 孙圣刚 段申汉 王细林 |
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| 作者单位： | Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Neurology Renmin Hospital of Wuhan University Wuhan 430060 China，Department of Neurology Renmin Hospital of Wuhan University Wuhan 430060 China |
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| 基金项目： | This project was supported by a grant from the National Educational Ministry of China （No. 20020487065）. |
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| 摘 要： | Over past years,it had been believed thatfunctions of astroglias(AS)were merely structuralsupport,neuronal nutrition or processing of exces-sive neurotransmitters or ions.It has recently beenreported that AS is not only involved in the con-ductance and integration of ion messages,and thetransmission,reaction and release of informationsubstances,but also plays a critical role in the“cross-talk”among neurons1,2].The relationshipbetweenthe AS and synaptic plasticity has been at-tracting atte…
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| 关 键 词： | CA1区域 大脑海马 小鼠 动物实验 神经细胞 |
| 收稿时间： | 2005-01-12 |
Regulation of astroglia on synaptic plasticity in the CA1 region of rat hippocampus |
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| Tan Laixun,Sun Shenggang,Duan Shenhan,Wang Xilin.Regulation of Astroglia on Synaptic Plasticity in the CA1 Region of Rat Hippocampus[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(5):484-487. |
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| Authors: | Tan Laixun Sun Shenggang Duan Shenhan Wang Xilin |
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| Institution: | 1. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China
2. Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China |
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| Abstract: | Summary The regulation of astroglia on synaptic plasticity in the CA1 region of rat hippocampus was examined. Rats were divided into
three groups: the newly born (<24 h), the juvenile (28–30 days) and the adult groups (90–100 days), with each group having
20 animals. The CA1 region of rat hippocampus was immunohistochemically and electron-microscopically examined, respectively,
for the growth of astroglia and the ultrastructure of synapses. The high performance liquid chromatography was employed to
determine the cholesterol content of rat hippocampus. In the newly-born rats, a large number of neurons were noted in the
hippocampal CA1 region of the newly-born rats, and few astroglia and no synaptic structure were observed. In the juvenile
group, a few astroglias and some immature synapses were found, which were less than those in adult rats (P<0.01). The cholesterol content was 2.92±0.03 mg/g, 11.20±3.41 mg/g and 12.91±1.25 mg/g for newly born, the juvenile and the
adult groups, respectively, with the differences among them being statistically significant (P<0.01). Our study suggests that the astrocytes may play an important role in the synaptic formation and functional maturity
of hippocampal neurons, which may be related to the secretion of cholesterol from astrocytes.
TAN Laixun, male, born in 1966, Associate Professor
This project was supported by a grant from the National Educational Ministry of China (No. 20020487065). |
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| Keywords: | astroglia synaptic ultrastructure cholesterol immunohistochemistry |
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