Synthesis and Evaluation of 99mTc-Labelled Monoclonal Antibody 1D09C3 for Molecular Imaging of Major Histocompatibility Complex Class II Protein Expression |
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Authors: | Gaurav Malviya E. F. J. de Vries Rudi A. Dierckx Alberto Signore |
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Affiliation: | (1) Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;(2) Nuclear Medicine Unit, Second Faculty of Medicine and Surgery, “Sapienza” University of Rome, Rome, Italy |
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Abstract: | Purpose It is known that major histocompatibility complex class II protein HLA-DR is highly expressed in B-cell lymphomas and in a variety of autoimmune and inflammatory diseases. Therefore, a radiolabelled fully humanized IgG4 monoclonal antibody (mAb) can provide useful prognostic and diagnostic information. Aims of the present study were to radiolabel an anti-HLA-DR mAb with technetium-99m and to evaluate its binding specificity, tissue distribution and targeting potential. |
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