CXCR4和MMP-2在卵巢上皮性肿瘤中的表达及意义

目的研究CXCR4和MMP-2在卵巢上皮性肿瘤中的表达情况及临床意义。方法应用免疫组织化学方法检测正常卵巢组织、良性上皮性卵巢瘤、卵巢癌、卵巢癌盆腔腹膜转移灶中CXCR4和MMP-2的表达，分析其与卵巢癌生物学特征之间的关系。结果CXCR4在卵巢癌及转移灶中的阳性率分别为60%、77.8%,明显高于正常卵巢组织（0）及卵巢良性肿瘤（0）；MMP-2在卵巢癌及转移灶中阳性率分别为85%、100%,明显高于正常卵巢组织（20%）及卵巢良性肿瘤（30%）（P均＜0.05）。两者的表达呈正相关。结论CXCR4和MMP-2在卵巢癌中表达明显上调，可能在卵巢癌发生发展过程中起重要作用。

Expression and Significance of CXCR4 and MMP-2 in Human Ovarian Epithelial Tumors

Objective To evaluate the expression of CXCR4 and MMP-2 in human ovarian tumors and to analyze the clinical significance. Methods Expression of CXCR4 and MMP-2 were examined by Immunohistochemistry in normal ovarian tissues, benign ovarian tumors, malignant ovarian carcinoma and peritoneal metastasis. The relationship between expression and biologic characteristic of ovarian carcinoma was analyzed. Results The positive expression of CXCR4 in ovarian cancer was 60%, in peritoneal metastasis 77.8%,which were higher than those in normal ovarian tissues and benign ovarian tumors. The positive expression of MMP-2 in ovarian cancer was 85%, in peritoneal metastasis 100%,which were higher than those in the normal ovarian tissues and benign ovarian tumors . The differences were significant(P<0.05) . The expression of these two proteins were correlated(P<0.05). Conclusion CXCR4 and MMP-2 may play great roles in the origin and progression of ovarian carcinoma.