Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice |
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| Authors: | Fickert Peter Fuchsbichler Andrea Wagner Martin Zollner Gernot Kaser Arthur Tilg Herbert Krause Robert Lammert Frank Langner Cord Zatloukal Kurt Marschall Hanns-Ulrich Denk Helmut Trauner Michael |
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| Affiliation: | Deparment of Medicine, Medical University, Graz, Austria. |
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| Abstract: | |
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| Keywords: | α-SMA, α-smooth muscle actin BECs, bile duct epithelial cells IL, interleukin KCs, Kupffer cells Mdr, multidrug resistance gene Mdr2−/−, Mdr2 (Abcb4) knock-out mice Mdr2+/+, wild-type controls PCR, polymerase chain reaction PSC, primary sclerosing cholangitis TGF-β1, transforming growth factor β TNF-α, tumor necrosis factor α ZO-1, zonula occludens protein-1 |
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