| 短时受精并即刻脱颗粒细胞对IVF-ET治疗周期的影响 |
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| 引用本文： | 刁英,杨智敏,谭兵兵,葛斌,杨名慧.短时受精并即刻脱颗粒细胞对IVF-ET治疗周期的影响[J].中国计划生育学杂志,2011,19(2):106-108,122. |
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| 作者姓名： | 刁英 杨智敏 谭兵兵 葛斌 杨名慧 |
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| 作者单位： | 遵义医学院第一附属医院生殖中心,563003 |
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| 摘 要： | 目的:了解体外受精-胚胎移植(IVF-ET)治疗中短时受精并即刻脱颗粒细胞对胚胎质量及结局的影响。方法:将316个IVF-ET周期按精卵受精时间不同及是否即刻脱颗粒细胞分为:短时受精并即刻脱颗粒细胞组(A组,精卵共孵育2h并即刻脱颗粒细胞)110个周期、短时受精并次日晨脱颗粒细胞组(B组,精卵共孵育2h并受精后18～19h脱颗粒细胞)108个周期和传统受精组(C组,精卵孵育过夜)98个周期。分别比较3组的受精率、多精受精率、卵裂率、优质胚胎率、妊娠率、胚胎种植率、流产率和分娩结局。结果:①3组的受精率、多精受精率、卵裂率和流产率差异无统计学意义(P>0.05);②A、B组的优质胚胎率、临床妊娠率和胚胎种植率显著高于C组(P分别<0.05或<0.01);③3组出生婴儿男女性别比例、新生儿出生体重差异无统计学意义(P>0.05),3组均无畸形胎儿出生。结论:①短时受精并即刻脱颗粒细胞不影响受精率、卵裂率和流产率,可提高优质胚胎率、临床妊娠率及胚胎种植率;②短时受精并即刻脱颗粒细胞能较准确判断卵子成熟度,观察第二极体是否排出,从而使补救卵细胞浆内单精子注射(ICSI)成为可能,进而可进一步严格控制ICSI适应证。
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| 关 键 词： | 短时受精 脱颗粒细胞 体外受精 |
Effect of short coincubation of gametes and removal of cumulus cells on outcome of in vitro fertilization and embryo transfer cycles |
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| Diao Ying,Yang Zhimin,Tan Bingbing,Ge Bin,Yang Minghui.Effect of short coincubation of gametes and removal of cumulus cells on outcome of in vitro fertilization and embryo transfer cycles[J].Chinese Journal of Family Planning,2011,19(2):106-108,122. |
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| Authors: | Diao Ying Yang Zhimin Tan Bingbing Ge Bin Yang Minghui |
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| Institution: | Diao Ying,Yang Zhimin,Tan Bingbing,Ge Bin,Yang Minghui The Reproductive Center of the First Affiliated Hospital of Zunyi Medical College,Zunyi 563003 |
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| Abstract: | Objective:To explore effects of short coincubation of gametes and removal of all cumulus cells on embryo quality and pregnancy outcome during in vitro fertilization cycles. Methods:A total of 316 cycles were randomly allocated to three groups,A (n=110,gamete co-incubating for 2 hours,then removing all cumulus cells),B (n=108,gamete co-incubating for 2 hours,removing all cumulus cells 18-19 hours after insemination) and C (n=98,gamete co-incubating overnight). The fertilization rate,polyspermy rate,cleavage ... |
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| Keywords: | Short coincubation of gametes Removal of cumulus cell in vitro fertilization |
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