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| 半胱氨酸蛋白酶-3在缺碘子代大鼠海马中的表达 | |
| 引用本文： | 李远慧,杨勤,陈辉蓉,韩冰,孙兰. 半胱氨酸蛋白酶-3在缺碘子代大鼠海马中的表达[J]. 贵阳医学院学报, 2004, 29(5): 400-401,404 |
| 作者姓名： | 李远慧 杨勤 陈辉蓉 韩冰 孙兰 |
| 作者单位： | 1. 贵阳医学院,组织胚胎学教研室,贵州,贵阳,550004 2. 贵阳医学院,病理生理学教研室,贵州,贵阳 550004 3. 贵阳医学院,数学教研室,贵州,贵阳 550004 |
| 基金项目： | 贵州省优秀科技教育人员省长专项基金资助 (S2 0 0 1 2 3) |
| 摘 要： | 目的 :探讨半胱氨酸蛋白酶 3(Caspase 3)对缺碘及甲状腺激素 (TH)不足海马神经细胞凋亡的影响 ,并研究缺碘所致学习记忆能力低下可能的机制。方法 :复制碘缺乏子代大鼠 ,免疫组织化学方法检测海马神经细胞Caspase 3表达。结果 :缺碘子代大鼠海马神经细胞Caspase 3较对照组明显增多 (16 12 0± 6 0 6 ,3 6 2 5±1 33) ,P <0 0 1。结论 :缺碘及甲状腺激素不足导致海马神经细胞凋亡增加 ,学习记忆能力低下 ,可能和Caspase 3明显增多有关。 |
| 关 键 词： | 半胱氨酸内肽酶类 海马 碘 缺乏症 大鼠 |
| 文章编号： | 1000-2707(2004)05-0400-02 |
The Expression and Significance of Caspase-3 in the Hippocampus of Rats Fed on Iodine Deficient Food |
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| LI Yuan-hui ,YANG Qin ,CHEN Hui-rong ,HAN Bing ,SUN Lan. The Expression and Significance of Caspase-3 in the Hippocampus of Rats Fed on Iodine Deficient Food[J]. Journal of Guiyang Medical College, 2004, 29(5): 400-401,404 | |
| Authors: | LI Yuan-hui YANG Qin CHEN Hui-rong HAN Bing SUN Lan |
| Affiliation: | LI Yuan-hui 1,YANG Qin 2,CHEN Hui-rong 3,HAN Bing 2,SUN Lan 2 |
| Abstract: | Objective: To investigate the expression of caspase-3 in the hippocampus of TH deficient rat to find its effect on apoptosis of hippocampus in iodine deficient (ID) rats.Methods: Animal model was developed with iodine deficient food, and the caspase-3 expression in hippocampus of ID rats was detected with immuohistochemistry method.Results: Caspase-3 expression was significantly higher in hippocampus of ID group than that in control group (P<0.01).Conclusions: Iodine deficiency and hypothyroidism could affect the increase of caspase-3, and this would result in the increasing of learning-memorising disorder and neuron apoptosis in hippocampus. |
| Keywords: | cysteine endopeptidases hippocampus iodine deficiency diseases rats |
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