Functional magnetic resonance imaging of methamphetamine craving |
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| Authors: | Jing-Jing Yin Shu-Hua Ma Ke Xu Zhao-Xin Wang Hong-Bo Le Jin-Zhuang Huang Ke-Ming Fang Ling-Min Liao Ze-Long Cai |
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| Affiliation: | 1. First Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China;2. Chaonan Minsheng Hospital of Shantou, Shantou 515144, China;3. Guangdong Key Laboratory of Medical Molecular Imaging, Shantou 515041, China;4. First Affiliated Hospital, China Medical University, Shenyang 110001, China;5. Shanghai Key Laboratory of Magnetic Resonance (East China Normal University), Shanghai 200062, China;6. Drug withdrawal Center, Shantou Public Security Bureau, Shantou 515041, China;7. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China |
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| Abstract: | The study aimed to explore the abnormal activation of special brain areas associated with methamphetamine craving using functional magnetic resonance imaging (fMRI) and to reveal the neurobiological basis of addiction. Twenty-six methamphetamine addicts and 26 healthy subjects were scanned by brain fMRI while watching pictures of happy, sad, or methamphetamine to acquire resource data. SPM5 was used to analyze fMRI data to get related brain activation map, and it was found that methamphetamine addicts had high brain activation in cingulate and low activation in frontal lobe when watching methamphetamine-cue pictures. This study demonstrated that methamphetamine addicts had emotion-related brain activation abnormalities. |
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