中国人群日本血吸虫再感染及其危险因素的Meta分析

目的 研究中国血吸虫病疫区人群血吸虫再感染及其危险因素。方法 计算机检索PubMed、CNKI、VIP和万方数据库,查找所有分析中国血吸虫病疫区人群血吸虫再感染及其危险因素的观察性研究。按纳入排除标准筛选文献、资料提取和质量评价,进行Meta分析。结果 共纳入18项研究,感染率研究对象12 604人,再感染率研究对象3 128人。血吸虫总感染率和总再感染率合并值分别为20.8%和 21.0%,两者差异比较,Z=1.12,P=0.26.再感染因素包括基线感染度、疫水接触指数、住址至感染性钉螺堤垸距离和年龄,其合并OR值及95%CI分别为3.58(1.56～8.22)、 2.37(1.08～5.22)、1.72(0.41～7.30)和0.48(0.19～1.23).结论 血吸虫总感染率和总再感染率差异无统计学意义。基线感染度、疫水接触指数、住址距有感染性钉螺堤垸距离是血吸虫再感染危险因素,年龄是其保护因素。

Reinfection of Schistosoma japonicum and related risk factors in Chinese:Meta-analysis

Objective To study the dynamics of the reinfection of Schistosoma japonicum and related risk factors among the people in schistosomiasis endemic areas in China. Methods Literature retrieval was conducted by using databases of PubMed, CNKI, VIP and Wanfang to collected all the data about the human re-infection of Schistosoma japonicum and related risk factors in the endemic areas in China. And a Mata-analysis was conducted on the literatures met the inclusion standards. Results Eighteen studies involving 12 604 people for infection survey and 3 128 people for re-infection survey were included in the analysis. The overall infection rate was 20.8%,and the overall re-infection rate was 21.0%. The difference had no statistical significance (Z=1.12,P=0.26). The re-infection related factors included baseline infection intensity (OR=3.58,95%CI:1.56-8.22); the index of contaminated water OR=2.37,95%CI:1.08-5.22);distance from house to river-side (OR=1.72,95%CI:0.41-7.30) and age (OR=0.48,95%CI:0.19-1.23). Conclusion The baseline infection intensity,the index of contaminated water and distance from house to river-side were the risk factors related to the re-infection of Schistosoma japonicum and age was a protective factor.