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| VEGF-C及其受体VEGFR-3在不同级别脑星形细胞瘤中的表达 | |
| 引用本文： | 叶秀峰,钟雪云,米粲,吴赤蓬. VEGF-C及其受体VEGFR-3在不同级别脑星形细胞瘤中的表达[J]. 诊断病理学杂志, 2005, 12(5): 365-367,i0013 |
| 作者姓名： | 叶秀峰 钟雪云 米粲 吴赤蓬 |
| 作者单位： | 1. 重庆医科大学,病理学教研室,重庆,400016 2. 暨南大学医学院,病理学教研室,广州,510632 3. 暨南大学医学院,公共卫生学教研室,广州,510632 |
| 基金项目： | 广东省科技厅研究团队项目课题(015012)，广州市科技局科研重点立项课题(2001-E-01-2)，国家科技部重大基础研究前期研究专项(2002ccc0400) |
| 摘 要： | 目的探讨血管内皮生长因子-C(VEGF-C)及血管内皮生长因子受体-3(VEGFR-3)在不同级别脑星形细胞瘤中的表达。方法检测50例不同级别脑星形细胞瘤患者手术切除标本中的VEGF-C和VEGFR-3的表达,并用抗FⅧ因子抗体标记瘤组织血管内皮细胞,计算肿瘤内微血管密度(IMVD)。结果VEGF-C和VEGFR-3阳性表达率分别为60%和52%。两者表达一致的符合率为74%。VEGF-C和VEGFR-3与脑星形细胞瘤病理分级呈显著正相关。结论脑星形细胞瘤中有VEGF-C和VEGFR-3的表达,其中VEGFR-3表达于血管。VEGF-C和VEGFR-3的表达与星形细胞瘤的病理分级相关。 |
| 关 键 词： | 星形细胞瘤 血管内皮生长因子-C 血管内皮生长因子受体-3 |
| 文章编号： | 1007-8096（2005）05-0365-03 |
| 收稿时间： | 2005-02-03 |
| 修稿时间： | 2005-02-03 |
Significance of expression of VEGF-C and VEGFR-3 in different histopathological grade of astrocytoma |
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| YE Xiu-feng , ZHONG Xue-yun , MI Can ,et al.. Significance of expression of VEGF-C and VEGFR-3 in different histopathological grade of astrocytoma[J]. Chinese Journal of Diagnostic Pathology, 2005, 12(5): 365-367,i0013 | |
| Authors: | YE Xiu-feng ZHONG Xue-yun MI Can et al. |
| Affiliation: | 1. Department of Pathology, Chongqing University of Medical Sciences, Chongqing 400016, China; 2. Department of Pathology, Jinan University Medical College, Guangzhou 510632, China |
| Abstract: | Objective To study the significance of expression of VEGF-C and VEGFR-3 in different histopathological grade of astrocytoma.Methods The Surgical specimens from 50 cases of brain astrocytoma were stained immunohistochemically for VEGF-C,VEGFR-3 and FVIII.Intratumoral microvessed density(IMVD) was calculated by labeling the endothelial cells of the blood vessels within the tumor. Results VEGF-C and VEGFR-3 expression were found in 60%(30/50),52%(26/50).VEGF-C,VEGFR-3 and FVIII expression was closely correlated with histopathological grades of astrocytoma. Conclusions VEGF-C and VEGFR-3 are presented in human brain astrocytoma.Blood vessels express VEGFR-3 positively in human astrocytoma.The expression of VEGF-C and VEGFR-3 is significantly associated with histopathological grade of astrocytoma. |
| Keywords: | Astrocytoma VEGF-C VEGFR-3 |
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