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| 环氧化酶-2在子宫内膜癌组织中的表达及意义 | |
| 引用本文： | 章兴凤,陈宏兵,黄华. 环氧化酶-2在子宫内膜癌组织中的表达及意义[J]. 中国交通医学杂志, 2010, 24(5) |
| 作者姓名： | 章兴凤 陈宏兵 黄华 |
| 作者单位： | 章兴凤,陈宏兵,ZHANG Xingfeng,CHEN Hongbing(如皋城东医院妇产科,江苏,226500);黄华,HUANG Hua(南通大学附属医院病理科) |
| 摘 要： | 目的:检测环氧化酶-2(cyclooxygenase-2,COX-2)在子宫内膜癌组织中的表达,并探讨其临床意义。方法:利用半定量RT-PCR法检测52例子宫内膜癌组织及23例正常子宫内膜组织中COX-2的表达。结果:(1)COX-2在正常子宫内膜组织中均不表达,在子宫内膜癌组织中的表达阳性率为65.4%。(2)COX-2表达量与肿瘤的分化程度有关,分化程度越低,表达量越高,高分化子宫内膜癌与低分化子宫内膜癌间差异有统计学意义(P<0.05)。结论:COX-2在子宫内膜癌中的表达高于正常组织,且与肿瘤的分化程度有关,提示COX-2与子宫内膜癌的形成有关,且可作为判断分化程度的指标。 |
| 关 键 词： | 子宫内膜癌 环氧化酶-2 半定量逆转录聚合酶链反应 |
Detection of Cyclooxygenase-2 in Endometrial Carcinoma |
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| ZHANG Xingfeng,CHEN Hongbing,HUANG Hua. Detection of Cyclooxygenase-2 in Endometrial Carcinoma[J]. Chinese Medical JOurnal of Communications, 2010, 24(5) | |
| Authors: | ZHANG Xingfeng CHEN Hongbing HUANG Hua |
| Abstract: | Objective:To investigate the expression of Cyclooxygenase-2(COX-2) in endometrial carcinoma.Method:Expression of COX-2 was assayed by semiquantitive RT-PCR in 52 cases of endometrial carcinoma and 23 cases of normal endometrial tissues.Result:(1)The positive rate and expression quantity of COX-2 in cancer tissues were higher than in normal tissues.(2)The expression quantity of COX-2 was correlated with the histological grade,and the expression quantity of COX-2 was lower in well-differentiated endometrial carcinoma than in poorly differentiated endometrial carcinoma.Conclusion:COX-2 may function importantly in tumor pro-duction and may be a good index to assess the differentiation degree and prognosis of endometrial carcinoma. |
| Keywords: | endometrial carcinoma cyclooxygenase-2 semiquantitive reverse transcrip polymerase chain reaction |
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