Inhibition by 5-hydroxytryptamine of anaphylactic histamine release from bovine granulocytes. |
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| Authors: | M C Holroyde P Eyre |
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| Affiliation: | Pharmacology Laboratory, Department of Biomedical Sciences, University of Guelph, Ontario, Canada |
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| Abstract: | ![]()
A suspension of granulocytes from calves sensitised to horse plasma released histamine when exposed to the antigen. Histamine release was strongly inhibited by 5-hydroxytryptamine in a dose-related fashion. 5-HT is known to be released from bovine lungs in vitro, and may regulate the release of histamine in vivo during anaphylaxis. |
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| Keywords: | Anaphylaxis Granulocyte Histamine 5-Hydroxytryptamine |
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