血液透析对慢性肾功能衰竭患者血浆内皮素影响的研究

为了研究内皮素（ＥＴ）在慢性肾功能衰竭（ＣＲＦ）患者中的变化，及血液透析（ＨＤ）对ＥＴ的影响，对４５例ＣＲＦ患者和３０例正常人采用放射免疫分析法（ＲＩＡ）测定血浆ＥＴ水平。结果显示，ＣＲＦ患者血浆ＥＴ明显升高，ＨＤ组明显高于非透析组；ＨＤ后血浆ＥＴ明业降低，ＣＲＦ组ＥＴ与血清肌酐（Ｓｃｒ）呈正相关，提示ＣＲＦ患者血浆ＥＴ的升高与肾功能损害有关；ＨＤ后ＥＴ下降与ＨＤ后钠潴留减少有关。

The Influence of Hemodialysis on Endothelin in Patients with Chronic Renal Failure

To investigate the changes of endothelin(ET) level in patients with chronic renal failure (CRF) and effects of hemodialysis on ET, forty-five patients with CRF were enrolled in this study, and 30 healthy adults were set as control. Plasma ET was measured by radioimmunoassay. Results: Plasma ET levels of CRF patients were significantly higher than those of the control (P<0. 001). ET levels in hemodialysis group were obviously different from the group without hemodialysis (P<0. 05),and ET levels decreased during hemodialysis (4~5hours) (P<0. 001). There was positive correlation between plasma levels of ET and concentration of serum creatinine (Scr) (r=0. 634 2,P<0. 001). Conclusion; Elevated plasma ET levels are observed in CRF patients .these changes may be related to the decrement of renal filtration. The plasma ET levels of CRF patients reduced significantly after dialysis, the changes may be related to the decrement of sodium and water retention.