| 应用植入控释系统进行一次法根管治疗术的动物实验研究 |
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| 引用本文： | 周群,何宏华,林晓平,王石池. 应用植入控释系统进行一次法根管治疗术的动物实验研究[J]. 牙体牙髓牙周病学杂志, 1997, 0(2) |
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| 作者姓名： | 周群 何宏华 林晓平 王石池 |
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| 作者单位： | 沈阳市中国医科大学第二临床学院 |
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| 摘 要： | 目的：利用自制含氯霉素、甲硝唑等药物的控释系统，对实验家兔的血药浓度、药物抗菌活性和家兔根管、尖周组织的病理观察，为今后临床应用提供理论和实验依据。方法：应用组织病理观察和液相色谱分析技术。结果：用ＨＰＬＣ法得出实验用家兔血药浓度和抗菌活性均为阴性，根管及尖周组织病理切片无特殊表现。结论：自制控释系统是一种无毒、无副作用、有效的根管治疗药物剂型，可进行临床应用。
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| 关 键 词： | 动物实验 根管治疗术 控释系统 |
An animal experiment study of immeidiate therapy of root canal with a controlled release delivery system |
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| Zhou Qun,He Honghua,Lin Xiaoping nd Clinical School,China Medical University,Shen Yang. An animal experiment study of immeidiate therapy of root canal with a controlled release delivery system[J]. Chinese Journal of Conservative Dentistry, 1997, 0(2) |
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| Authors: | Zhou Qun He Honghua Lin Xiaoping nd Clinical School China Medical University Shen Yang |
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| Affiliation: | Zhou Qun,He Honghua,Lin Xiaoping 2nd Clinical School,China Medical University,Shen Yang 110003 |
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| Abstract: | Aim: The concentreation of drugs and MIC in rabbit's serum were observed with a new kind of the controlled release delivery system (CRDS), after that, histological observation of rabbits pulp and root canal was done. In order to provide scientific basis for clinical apply. Methods: Using histopathological observation and HPLC technique. Results: There was no positive outcome for both concentration of drugs and MIC in the serum by HPLC method, meanwhile, there was no abnormal change in histological observation. Conclusions: The new kind of the CRDS can be used in clinical practice because it is a safe and reliable drug system for root canal therapy. |
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| Keywords: | animal experiment root canal therapy controlled release delivery system |
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