Respiratory deterioration during growth hormone therapy in a case of congenital nemaline myopathy期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Respiratory deterioration during growth hormone therapy in a case of congenital nemaline myopathy

Authors:	K. Logghe J. M. Wit F. Jennekens J. E. H. Pruijs

Affiliation:	(1) Department of Paediatrics, Endocrinology Division, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, P. O. Box 18009, 3501 CA Utrecht, The Netherlands;(2) Orthopaedic Surgery, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, P. O. Box 18009, 3501 CA Utrecht, The Netherlands;(3) Department of Neuromuscular Disease, University Hospital, Utrecht, The Netherlands

Abstract:	Congenital nemaline myopathy (CNM) is generally classified as a non-progressive or slowly progressive neuromuscular disease. We describe a boy with CNM and an isolated partial growth hormone (GH) deficiency. From the onset of GH therapy his respiratory capacity deteriorated rapidly. The possible association between this deterioration and GH therapy is discussed.

Keywords:	Nemaline myopathy Growth hormone therapy Respiratory failure Cardiac failure Mechanical ventilation
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