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Bioenergetics of T cell activation and death in HIV type 1 infection
Authors:Visalli Giuseppa  Bertuccio Maria Paola  Currò Monica  Pellicanò Giovanni  Sturniolo Giuseppe  Carnevali Andrea  Spataro Pasquale  Ientile Riccardo  Picerno Isa  Cavallari Vittorio  Piedimonte Giuseppe
Affiliation:Department of Hygiene, Public Health and Preventive Medicine, University of Messina, Italy. giusyvisalli@yahoo.it
Abstract:
Regressive morphological lesions, found in peripheral lymphocytes from HIV(+) patients, clearly conflict with normal cycle progression and with the execution of basic housekeeping and immune functions. With these lesions, circulating lymphocytes are destined to spontaneous and energy-independent cell lysis. By means of confocal microscopy and morphometry, we have quantified the rate of circulating T cells that are probably destined to emocatheresis in vivo. This rate includes lymphocytes in which nucleolin fragments have been scattered out of the nuclear region as a result of prelethal alterations in the nuclear membrane permeability. In terms of bioenergetics, these cells show evident anomalies in the energy production machinery that make them unable to carry out ATP-requiring functions. The extent of damaged cell fraction in peripheral blood reflects the frequency with which T lymphocytes leave lymphoid tissue to be cleared in hemocatheretic processes.
Keywords:
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