高血压病中医证型与心血管危险因素的相关性研究

目的 初步探索上海及周边地区高血压病中医证型与心血管危险因素的相关性.方法 按纳入标准选择原发性高血压病患者213例,充分收集中医四诊信息,对其进行辨证分型,并进行统计分析.结果 （1）高血压各证型分布比例从高到低依次为肝肾阴虚证,肝阳上亢证,阳气虚衰证,气阴两虚证,痰湿壅盛证.（2）高血压不同中医证型与心血管危险因素的比较.①高血压不同中医证型组年龄从高到低依次为阳气虚衰证,肝肾阴虚证,痰湿壅盛证,肝阳上亢证,气阴两虚证,高血压不同中医证型组间在病程、性别中未见明显差异;②高血压不同中医证型组血同型半胱氨酸均值均高于指南界定范围（≥10 mmol/mL）,各组间比较差异无统计学意义;③高血压不同中医证型组空腹血糖水平从高到低依次为气阴两虚证,阳气虚衰证,肝肾阴虚证,肝阳上亢证,痰湿壅盛证;高血压不同中医证型组糖化血红蛋白水平从高到低依次为气阴两虚证,阳气虚衰证,肝肾阴虚证,痰湿壅盛证,肝阳上亢证;各证型组餐后2h血糖差异无统计学意义;④高血压不同中医证型组三酰甘油水平从高到低依次为痰湿壅盛证,气阴两虚证,阳气虚衰证,肝肾阴虚证,肝阳上亢证;高血压不同中医证型组高密度脂蛋白水平从高到低依次为肝肾阴虚证,痰湿壅盛证,肝阳上亢证,阳气虚衰证,气阴两虚证,各证型组其余血脂指标差异无统计学意义.结论 肝肾阴虚证在高血压患者中所占比重最高;阳气虚衰证组患者年龄最大;各证型高血压患者血同型半胱氨酸水平普遍较高;气阴两虚证组患者血糖水平最高;痰湿壅盛证患者甘油三酯最高.

As sociation Study between TCM Syndrome Types and Cardiovascular Risk Factors

Objective： To study the correlation between TCM syndrome types and cardiovascular risk factors of patients with hypertension in Shanghai and its surrounding areas. Methods： According to the inclusion criteria, 213 patients with essential hypertension were selected. TCM diagnostic information and results of biochemical indexes were collected,and the relationship between patient＇s TCM syndrome types and cardiovascular risk factors was studied. Results： （1） TCM syndrome types distributions from highest to lowest in hypertension were liverkidney Yin deficiency,liver-Yang hyperactivity,Yang deficiency,both Qi and Yin deficiency,excess accumulation of phlegm-dampness. （2）Comparison of cardiovascular risk factors in different TCM syndrome types： （1）The age in different syndromes from high to low was as follows： Yang deficiency,liver-kidney Yin deficiency,excess accumulation of phlegm-dampness, liver-Yang hyperactivity, both Qi and Yin deficiency. But there were no statistical differences in disease course and gender among different syndrome types. （2）The blood homocysteine value in all TCM syndrome types was higher than average guide scope （≥ 10 mmol/mL）, but there was no significant difference among groups. （3）The value of fasting blood glucose in different syndromes from high to low was as follows： both Qi and Yin deficiency,Yang deficiency,liver-kidney Yin deficiency,liver-Yang hyperactivity,excess accumulation of phlegm-dampness. The value of glycosylated hemoglobin in different syndromes from high to low was as follows： both Qi and Yin deficiency,Yang deficiency,liver-kidney Yin deficiency,excess accumulation of phlegm-dampness,liver-Yang hyperactivity ;but there was no statistical difference in 2 hour postprandial blood glucose among different syndrome types. （4）The value of TG in different syndromes from high to low was as follows： excess accumulation of phlegm-dampness,both Qi and Yin deficiency,Yang deficiency,liver-kidney Yin deficiency ,liver-Yang hyperactivity