窄谱中波紫外线对寻常性银屑病患者外周血MCP-4表达水平的影响

目的探讨窄谱中波紫外线(NB-UVB)对寻常性银屑病患者外周血中单核细胞趋化蛋白-4(MCP-4/CCL13)表达的影响。方法采用夹心酶联免疫吸附法检测24例寻常性银屑病患者NB-UVB治疗前后和24例健康人外周血血清MCP-4水平。结果 24例寻常性银屑病患者患者血清MCP-4水平为(255.35±79.31)pg/mL,正常人对照组血清MCP-4水平为32.43±10.41pg/mL,两组差异有显著性(t=13.145,P0.05)。经NB-UVB治疗12周后,银屑病患者MCP-4水平明显下降(88.19±23.97)pg/mL,与治疗前差异有显著性(t=9.229,P0.05)。结论 NB-UVB可以降低寻常性银屑病患者血清中MCP-4的表达水平,MCP-4可能参与了角质形成细胞的增殖,参与银屑病的发病过程。

Effect of Narrowband Ultravoilet B Phototherapy on Chemokine MCP-4 in Psoriasis

Objective To study the impact of expression level of monocyte chemoattractant protein-4 (MCP-4/CCL13) in peripheral blood of psoriasis vulgaris who received the narrow-band ultraviolet B (NB-UVB) therapy.Methods Sandwich enzyme-linked immunosorbent assay was used to detected peripheral blood levels of serum MCP-4 in 24 cases of psoriasis vulgaris before and after treatment with NB-UVB and 24 healthy human.Results Twenty four cases of psoriasis vulgaris showed serum level of MCP-4 was (255.35±79.31)pg/mL,and normal control group was (32.43±10.41)pg/mL,which had statistically significant (t=13.145,P<0.05) difference.After NB-UVB treatment for 12 weeks,MCP-4 levels in psoriasis patients were significantly decreased (88.19±23.97)pg/mL,which had statistically significant difference compared with before(t= 9.229,P<0.05).Conclusion NB-UVB can reduce the serum level of MCP-4 in patients with psoriasis vuigaris,and MCP-4 may be involved in value-added keratinocytes prolifer-ation and pathogenesis of psoriasis.