缬沙坦对慢性心力衰竭患者心率变异性的影响

目的：探讨缬沙坦对慢性心力衰竭（CHF）患者心率变异性（HRV）的影响。方法：90例CHF患者随机分为缬沙坦组（45例）和对照组（45例）。缬沙坦组在常规治疗基础上加用缬沙坦80～160mg/d；对照组常规治疗。两组治疗前、治疗后8周检测HRV的变化。结果：缬沙坦组和对照组治疗后HR明显低于治疗前（P〈0.01）；缬沙坦组治疗后SDNN、SDANN、SDNN index明显高于对照组（P〈0.05）。结论：缬沙坦可能对CHF患者心脏自主神经功能产生有益作用而提高HRV，从而改善患者预后。

Effect of valsartan on heart rate variability in patients with chronic heart failure

Objective：To study the effect of valsartan on heart rate variability （HRV） in patients with chronic heart failure （CHF）.Methods： 90 cases of the patients with CHF were randomly divided into valsartan group （n=45） and control group （n=45）. Valsartan 80-160 mg/d was administered in addition to the routine treatment for valsartan group; the control group received the routine treatment. The changes of HRV in the two groups were detected before and after eight weeks. Results：HR after treatment was significandy lower than that before treatment in two groups （P〈0.01）; after treatment SDNN, SDANN, SDNN index in valsartan group were significantly higher than those in control group （P〈0.05）. Conclusion：Valsartan may cardiac autonomic nerve function and have a useful role in raising HRV to improve the prognosis for patients with CHF.