| Srmir￡2与肿瘤关系的研究进展 |
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| 引用本文： | 郭晓玲,曹勤,蔡瑜,沈锡中.Srmir￡2与肿瘤关系的研究进展[J].胃肠病学,2014(1):54-56. |
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| 作者姓名： | 郭晓玲 曹勤 蔡瑜 沈锡中 |
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| 作者单位： | [1]上海中医药大学附属普陀医院消化科,200062 [2]复旦大学附属中山医院消化科,200062 |
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| 摘 要： | Smad泛素化调节因子2（Smuff2）属于泛素蛋白水解酶途径中的一种E3泛素连接酶。研究发现Smurf2与肿瘤的发生、发展密切相关，其在肿瘤中的作用并不单纯依赖于泛素连接酶活性，亦可通过其他方式参与细胞增殖、凋亡、衰老、迁移等过程，从而调控肿瘤的发展。本文就Smurf2与肿瘤关系的研究进展作一综述。
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| 关 键 词： | Smurt2 肿瘤 E3泛素连接酶 细胞增殖 |
Advances in Study on Relationship between Smurf2 and Tumor |
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| GUO Xiaoling^,CAO Qin^,CAI Yu^,SHEN Xizhong.Advances in Study on Relationship between Smurf2 and Tumor[J].Chinese Journal of Gastroenterology,2014(1):54-56. |
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| Authors: | GUO Xiaoling^ CAO Qin^ CAI Yu^ SHEN Xizhong |
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| Institution: | ^2. 1Department of Gastroenterology, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai (200062); 2Department of Gastroenterology, Zhongshan Hospital Fudan University, Shanghai Correspondence to： CAO Qin, Email： caoqin434@ sina. com |
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| Abstract: | Smad ubiquitination regulatory factor 2 （Smurf2） is a E3 ubiquitin ligase involved in ubiquitin hydrolase pathway. Studies have shown that Smud2 is closely associated with the development and progression of tumor. Its effect on tumor does not simply depend on its ubiquitin ligase activity, but also through other ways involved in cell proliferation, apoptosis, senescence and migration to regulate the development and progression of tumor. This article reviewed the advances in study on relationship between Smurf2 and tumor. |
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| Keywords: | Smurt2 Neoplasms E3 Ubiquitin Ligase Cell Proliferation |
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