氟化亚锡牙膏对牙本质敏感症脱敏作用的Meta分析

目的 对有关含氟化亚锡牙膏治疗牙本质敏感症的随机对照试验（RCT）进行Meta分析，评价其治疗牙本质敏感症的疗效。方法依照Cochrane系统评价员手册（5.1.0版本）指导进行分析，包含检索策略、纳入排除标准、数据提取及质量评价。通过计算机检索CNKI、CBM、PubMed、Embase数据库和Cochrane Library，查找有关含氟化亚锡牙膏治疗牙本质敏感症的RCT，检索时间截至2015年1月。由2位研究者独立根据纳入与排除标准进行文献筛选、资料提取和质量评价后，采用RevMan 5.3软件进行Meta分析。结果共纳入6个RCT，包括494例患者（试验组247例，对照组247例）。氟化亚锡脱敏牙膏治疗牙本质敏感的Meta分析结果显示，触压探诊敏感测试（SMD=1.41，95%可信区间为0.74~2.09）及冷空气喷吹测试（SMD=-1.16，95%可信区间为-1.84~-0.48）的差异均有统计学意义（P<0.000 01），氟化亚锡脱敏牙膏治疗牙本质敏感症的效果较好。结论现有证据表明，氟化亚锡脱敏牙膏治疗牙本质敏感症的效果较好；但纳入研究的语种、地区及质量有一定局限性，且样本量较小，仍需更多高质量、大样本的RCT以进一步验证。

Desensitizing effect of stannous fluoride-containing toothpaste for patients with dentine hypersensitivity: a Meta-analysis

Objective This study aims to assess the effects of desensitizing toothpaste containing stannous fluoride on dentine hypersensitivity by performing Meta-analysis of randomized controlled trials (RCT) involving the treatment of dentine hypersensitivity with stannous fluoride-containing toothpaste. Methods The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as CNKI, CBM, PubMed, Embase, and Cochrane Library up to January 2015. RCT of treating dentine hypersensitivity with stannous fluoride-containing toothpaste were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers. Meta-analysis was performed with RevMan 5.3 software. Results Six RCT with 494 patients (247 in the experimental group and 247 in the control group) were included. The results of Meta-analysis showed that the desensitizing effect of stannous fluoride-containing toothpaste was significantly better than that of control in tactile sensitivity test (SMD=1.41, 95% confidence interval 0.74–2.09, P<0.000 01) and air blast test (SMD=-1.16, 95% confidence interval -1.84–-0.48, P<0.000 01). Conclusion Current evidence shows that stannous fluoride-containing toothpaste is effective in treating dentine hypersensitivity in clinic. However, due to limited sample size and lower quality of the included studies, more high quality and large-sample RCT are needed to further verify the evidence.