硒蛋白-P在大肠癌组织中的表达及临床意义

目的：研究硒蛋白-P在大肠癌、转移淋巴结及正常大肠组织中的表达情况,探讨其在大肠癌发生、发展中的作用。方法：采用免疫组织化学方法检测81例大肠癌组织和20例癌旁正常黏膜中硒蛋白-P的表达。结果：硒蛋白-P在大肠癌、转移淋巴结组织中的阳性表达率分别为53.1%（43/81）和55.7%（39/70）,在正常黏膜中的阳性表达率为80.0%（16/20）,硒蛋白P在正常大肠黏膜中的表达明显高于大肠癌组织（P〈0.05）,且硒蛋白-P在大肠癌组织中的表达与肿瘤的大体类型、大小、分化程度、浸润深度及有无转移淋巴结等临床病理因素无关（P〉0.05）。且患者5年存活率与硒蛋白-P在大肠癌组织中的表达无关（P〉0.05）。结论：硒蛋白-P在大肠癌组织中表达降低,提示其可能在大肠癌的发生、发展过程中起重要作用,但不能作为判断预后的指标。

Expression and significance of selenoprotein-P in the tissues of colorectal cancer

Objietive： To investigate the expression and significance of selenoprotein-P in colorectal cancer,metastatic lymph node and adjacentmucosa of colorectal cancer,and discuss the effect of selenoprotein-p on occurring and developing of colorectal cancer.Methods： The expression of selenopreotein-P in adjacentmucosa of colorectal cancer,and in the cancer、 metastatic lymph node were detected by means of immunohistochemistry.Results： The positive rate of selenorotein-P were 53.1%,55.7%,80.0% in tumor cell,metastatic lymph node and adjacentmucosa of colorectal cancer.The expression of adjacentmucosa was significantly higher than that two sites（χ^2=4.87,P〈0.05）.The positive of selenoprotein-P expression in the tissues of colorectal cancer was not related to other pathological factors.Conclusions： The expression of selenoprotein-P is low in colorectal cancer,and may play an important role in occurring and developing of colorectal cancer.