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| 黑米花色素苷对大鼠血液生化指标和巨噬细胞功能影响的研究 | |
| 引用本文： | 刘明达,钱松,金丽琴. 黑米花色素苷对大鼠血液生化指标和巨噬细胞功能影响的研究[J]. 营养学报, 2010, 32(1) |
| 作者姓名： | 刘明达 钱松 金丽琴 |
| 作者单位： | 1. 温州医学院附属第一人民医院,温州,325035 2. 温州医学院药学院,温州,325035 3. 温州医学院基础医学院生化教研室,温州,325035 |
| 基金项目： | 国家自然科学基金(No.S060214) |
| 摘 要： | 目的观察黑米花色素苷(black rice anthocyanin,BA)对大鼠血液生化指标的影响及其对腹腔巨噬细胞(peritoneal macrophage,PM)与肺泡巨噬细胞(alveolar macrophage,AM)的激活作用,探讨其对大鼠的免疫调节作用。方法雌性SD大鼠24只,随机分为对照组和BA低(BAL,25mg/kgbw),中(BAM,50mg/kgbw),高(BAH,100mg/kgbw)剂量组4组。除对照组给生理盐水外,另三组分别给予相应剂量的BA,1/d连续30d。实验结束时,从股动脉取血,用生化方法测定巨噬细胞内乳酸脱氢酶(LDH)、酸性磷酸酶(ACP)、超氧化物歧化酶(SOD)活力、及丙二醛(MDA)含量,并进一步观察巨噬细胞摄取中性红的能力。结果BA组大鼠血液中尿素氮(UN)、尿酸(UA)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)水平都有不同程度的降低,PM内ACP、LDH活力显著升高,PM和AM内SOD活力升高,MDA水平降低,而且能显著增强PM、AM的吞噬能力。结论BA对大鼠血液和巨噬细胞生化指标有重要的免疫调节作用。 |
| 关 键 词： | 黑米 花色素苷 血液生化 巨噬细胞 |
EFFECT OF BLACK RICE ANTHOCYANIN ON BIOCHEMICAL INDICATORS IN BLOOD AND MACROPHAGES OF RATS |
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| LIU Ming-da,QIAN Song,JIN Li-qing. EFFECT OF BLACK RICE ANTHOCYANIN ON BIOCHEMICAL INDICATORS IN BLOOD AND MACROPHAGES OF RATS[J]. Acta Nutrimenta Sinica, 2010, 32(1) | |
| Authors: | LIU Ming-da QIAN Song JIN Li-qing |
| Affiliation: | LIU Ming-da,QIAN Song1,JIN Li-qing2 (Department of Biochemistry,School of Basic Medical Science,1 The First Affiliated Hospital,2School of Phamacy,Wenzhou Medical College,Wenzhou 325035,China) |
| Abstract: | Objective To investigate the immunomodulatory effect of black rice anthocyanin(BA) on biochemical indicators in blood and macrophages in rats.Method Twenty four female SD rats were randomly divided into 4 groups:control group,BA low,middle and high-dose groups(BAL 25;BAM 50;BAH 100 mg/kg bw).The control group was treated with normal saline,while BA groups were i.g.administered with defferent doses for 30 d.The blood biochemical indicators were detected by automatic biochemistry analyzer.The activities of la... |
| Keywords: | black rice anthocyanin biochemical indicator macrophages |
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