Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study |
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| Affiliation: | 1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People''s Republic of China;2. Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People''s Republic of China;1. Department of Cognitive Psychology and Methodology, University of Basel, Switzerland;2. Department of Biological and Medical Psychology, University of Bergen, Norway;3. Division of Pediatric Neurology and Developmental Medicine, University Children''s Hospital Basel, Switzerland;1. Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, via Altura 3, 40139 Bologna, Italy;2. Health Medical Centre, via della Chiusetta 14, 17021 Alassio, Italy;3. DISFOR Psychology, University of Genoa, Polo M.T. Bozzo, vico S. Antonio 5/7, 16121 Genova, Italy;1. Department of Neurosurgery, The First Affiliated Hospital of USTC, Anhui Provincial Hospital Affiliated to Anhui Medical University, 17 Lujiang Road, Hefei, Anhui Province 230001, China;2. School of Neurosurgery, Anhui Medical University, 81 Meishan Road, Hefei, Anhui Province 230032, China;3. Anhui Provincial Institute of Stereotactic Neurosurgery, 9 Lujiang Road, Hefei, Anhui Province 230001, China |
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| Abstract: | ![]()
It is noteworthy that some children with benign childhood epilepsy with centrotemporal spikes (BECTS) show attention problems despite their favorable seizure outcome. Resting-state functional magnetic resonance imaging (fMRI) is a method widely used to detect brain network alterations in neuropsychiatric diseases. We used resting-state functional magnetic resonance imaging (fMRI) to investigate specific brain networks related to attention deficit in children with BECTS. Resting-state fMRI was performed in patients with BECTS with ADHD (n = 15) and those with BECTS without ADHD (n = 15) and in healthy controls (n = 15). Unbiased seed-based whole-brain functional connectivity analysis was used to study the connectivity pattern of three resting-state networks, including the ventral attention network (VAN) and the dorsal attention network (DAN) and the default mode network (DMN). Patients with BECTS with ADHD displayed decreased functional connectivity in the DAN compared with other two groups, while patients with BECTS without ADHD showed increased functional connectivity in the DAN. Moreover, we found increased functional connectivity in the VAN and in the DMN in patients with BECTS with or without ADHD when comparing with controls. These results showed that the newly-diagnosed children with BECTS displayed brain activity alterations in the ventral and dorsal attention networks. The difference in the extent of impairment in the dorsal attention network of patients with BECTS with ADHD and patients with BECTS without ADHD may lead to improved understanding of the underlying neuropathophysiology and treatment of BECTS with ADHD and BECTS without ADHD. |
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