Chemokine expression and leucocyte infiltration in Sjogren's syndrome |
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Authors: | Cuello, C Palladinetti, P Tedla, N Di Girolamo, N Lloyd, AR McCluskey, PJ Wakefield, D |
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Affiliation: | Inflammation Research Unit, School of Pathology, The University of New South Wales, Sydney, Australia. |
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Abstract: | ![]() OBJECTIVE: To investigate the expression and source of chemokines in minorsalivary gland biopsies (MSGs) in patients with Sjogren's syndrome (SS).METHODS: Immunohistochemical analysis was used to determine the pattern ofchemokine expression in MSGs from patients with (n=6) and without (n=5) SS,as well as to examine the phenotype of both resident and infiltrating cellsexpressing chemokines. RESULTS: Significant differences in the number ofinfiltrating mononuclear (MN) cells in patients with and without SS werenoted. Ductal epithelial cells of SS biopsies expressed significantlyincreased levels of macrophage inflammatory protein (MIP)-1alpha,MIP-1beta, interleukin-8 (IL-8) and RANTES (Regulated upon Activation,Normal T cell Expressed and Secreted). Biopsies from patients with SSshowed that MIP-1beta was expressed by 51% of infiltrating cells, while 41%expressed MIP-1alpha, whereas 22 and 7% expressed RANTES and IL-8,respectively. CONCLUSION: Chemokines expressed by ductal epithelial cellsmay attract circulating leucocytes, in particular CD4+ T cells, towards thesite of inflammation, thereby orchestrating the influx of MN cellscharacteristically seen in MSGs in SS. Chemokines may be induced directlyby a putative triggering agent for SS, or secondary to the release ofpro-inflammatory cytokines produced by epithelial cells. These findingsfurther implicate epithelial cells as playing a major role in thepathogenesis of SS and implicate chemokines in the leucocyte recruitment inthis setting. |
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