肿瘤标志物联合检测对肝外胆道梗阻的诊断价值

目的评价CA19-9、CA125与CEA联合检测对肝外胆道梗阻的鉴别诊断价值。方法采用化学发光免疫分析法测定97例肝外胆道梗阻患者血清CA19-9、CA125及CEA水平,进行统计分析。结果 CA19-9在恶性梗阻时的阳性率明显高于CEA和CA125（P〈0.01）,三项联检,诊断准确率可提高至89.1%。结论血清CA19-9、CA125与CEA联合检测对肝外胆道梗阻的鉴别诊断具有一定价值,CEA和CA125还可以为恶性梗阻的腹腔转移提供可靠信息。

The Study of the clinical application of tumor markers in extrahepatic biliary obstruction

Objective To evaluate the value of serum tumor markers in differentiate diagnosis of extrahepatic biliary obstruction.Methods Using the chemiluminescence immunoassay to measure the CA19-9,CA125 and CEA levels in serum of the patients who had extrahepatic biliary obstruction.The statistical analysis based on these results was carried out.Results The positive rate of CA19-9 was higher than those of CA125 and CEA in malignant obstructions（P0.01）.Combined with,the accuracy rate of diagnose was significantly high to 89.1%.Conclusion The combination of CA19-9,CA125 and CEA can provide excellent accuracy information in the differentiate diagnosis of extrahepatic biliary obstruction.CEA and CA125 can also provide information of metastasis in malignant obstructions.