11C-methionine uptake in cerebrovascular disease: A comparison with18F-FDG PET and99mTc-HMPAO SPECT |
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| Authors: | Makoto?Nakagawa mailto:nanchan-kyu@umin.ac.jp" title=" nanchan-kyu@umin.ac.jp" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Yasuo?Kuwabara,Masayuki?Sasaki,Hirofumi?Koga,Tao?Chen,Kouichirou?Kaneko,Kazutaka?Hayashi,Takato?Morioka,Kouji?Masuda |
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| Affiliation: | Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. nanchan-kyu@umin.ac.jp |
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| Abstract: | ![]()
OBJECTIVES: Carbon-11-L-methyl-methionine (11C-methionine) has been reported to be useful for evaluating brain tumors, but several other brain disorders have also shown signs of high methionine uptake. We retrospectively evaluated the significance of 11C-methionine uptake in cerebrovascular diseases, and also compared our results with those for 18F-FDG PET and 99mTc-HMPAO SPECT. METHODS: Seven patients, including 3 patients with a cerebral hematoma and 4 patients with a cerebral infarction, were examined. All 7 patients underwent both 11C-methionine PET and 99mTc-HMPAO SPECT, and 6 of them underwent 18F-FDG PET. RESULTS: A high 11C-methionine uptake was observed in all 3 patients with cerebral hematoma. Increased 99mTc-HMPAO uptake was observed in 2 out of 3 patients, and all 3 patients had decreased 18F-FDG uptake. Of 4 patients with a cerebral infarction, high 11C-methionine uptake was observed in 3. Increased 99mTc-HMPAO uptake was also observed in one patient, whereas 3 patients had decreased 18F-FDG uptake. CONCLUSIONS: We should keep in mind that high 11C-methionine uptake is frequently observed in cerebrovascular diseases. CVD should therefore be included in the differential diagnosis when encounting patients with a high 11C-methionine uptake. |
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| Keywords: | 11C-methionine PET cerebrovascular disease 18F-FDG 99mTc-HMPAO |
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