倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果观察

目的观察使用倍他司汀联合盐酸氟桂利嗪对耳鸣的治疗效果和安全性，以提高耳鸣的治疗效果。方法2011年2月～2012年11月收治的70例耳鸣患者随机分为两组，实验组（35例）患者使用倍他司汀联合盐酸氟桂利嗪治疗；对照组（35例）患者单独使用盐酸氟桂利嗪治疗，比较两组患者的治疗效果。结果实验组总有效31例，对照组总有效15例，两组患者的治疗效果比较，差异具有统计学意义（P〈0．05）；实验组患者的不良反应与对照组患者比较，差异无统计学意义（P〉0．05）。结论使用倍他司汀联合盐酸氟桂利嗪对耳鸣患者进行治疗具有较好的治疗效果，且安全性更高，值得临床推广。

Therapeutic effect of betahistine combined with flunarizine hydrochloride for treatment of tinnitus

Objective To observe the efficacy and safety of betahistine combined with flunarizine hydrochloride for the treatment of tinnitus. Methods From Feb 2011 to Nov 2012, 70 patients with tinnitus were hospitalized in our department. All the patients were randomly divided into experimental group and control group equally. Patients of the experimental group received betahistine combined with flunarizine hydrochloride, and those of the control group were given flunarizine hydrochloride only. The therapeutic and adverse effects of both groups were evaluated. Results The effective rate of the experimental group was 88.57% （31/35） , while that of the control group was 42.86% （15/35）. The difference of effective rate between the two groups was statistically significant （P 〈 0.05 ） while that of the adverse effect rate was insignificant （ P 〉 0.05 ）. Conclusion With advantages of good clinical effect and safety in the treatment of tinnitus, betahistine combined with flunarizine hydroehloride is worthy of clinic application.