| 牛磺酸对离体大鼠脊髓缺氧／复氧损伤的保护作用 |
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| 引用本文： | 姚兴海 王吉先. 牛磺酸对离体大鼠脊髓缺氧／复氧损伤的保护作用[J]. 基础医学与临床, 1998, 18(3): 57-60,56 |
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| 作者姓名： | 姚兴海 王吉先 |
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| 作者单位： | [1]北京医科大学心血管基础研究所 [2]山东铝业公司职工医院 |
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| 摘 要： | 本文在孵育的离体大鼠脊髓组织切片上，观察牛磺酸对缺氧／复氧损伤的影响，缺氧／复氧损伤引起大鼠脊髓组织ＡＴＰ含量减少和ＬＤＨ漏出增多，ＮＯ生成和ＮＯＳ活性明显增加，Ｌ－精氨酸转运Ｖｍａｘ增加９７％（Ｐ〈０．０１），Ｋｍ值无明显变化，用１０和２０ｍｍｏｌ／Ｌ牛磺酸卵育与单纯缺氧／臭氧组比较，显著减轻了缺氧／复氧引起的组织ＡＴＰ减少和ＬＤＨ漏出，ＮＯ生成分别低３４％（Ｐ〈０．０１）和４０％（Ｐ〈０．０１
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| 关 键 词： | 脊髓损伤 缺氧 复氧 牛磺酸 保护作用 |
Experimental Study of Taurine Protective Effect on Hypoxia/ Reoxygenation in Isolated Rat Spinal Cord |
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| Wang Jixian Yao xinghai Wang Lizhi Li Yan Su jingyi Tang Chaoshu. Experimental Study of Taurine Protective Effect on Hypoxia/ Reoxygenation in Isolated Rat Spinal Cord[J]. Basic Medical Sciences and Clinics, 1998, 18(3): 57-60,56 |
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| Authors: | Wang Jixian Yao xinghai Wang Lizhi Li Yan Su jingyi Tang Chaoshu |
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| Abstract: | The effect of taurine on hypoxia/reoxygenation(H/R) injury in tissue slices of isolated rat spinal cord was investigated.There are decrease of ATP content,increase of LDH leakage,No production and NO Synthase(NOS)activity were obviously elevated during H/R.Maximum transport velocity(Vmax)of L Arginine(L Arg)is 97% higher(P<0 01),while Michaelis Constant(Km)showed no significant changes.In comparison with H/R group,10 and 20 mmol taurine could significantly alleviate ATP decrease and LDH leakage;NO production reduced 34% (P<0 01) and 40%(P<0 01)respectively.Vmax of L Arg lowered 32%(P<0 01) and 38%(P<0 01).But NOS activity was slightly inhibited.Thus it might be suggested that effect of taurine on L Arg /NO sytem may be one of the nervous protective mechanisms during H/R injury. |
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| Keywords: | hypoxia/reoxygenation taurine L Arginine transport |
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