急性白血病合并DIC53例临床分析

对５３例ＡＬ合并ＤＩＣ作回顾分析，并发ＤＩＣ的ＡＬ类型为ＡＰＬ２８例，非Ｍ３型ＡＮＬＬ１５例、ＡＬＬ１０例，发生于初发期、诱导化疗和化疗间歇期、难治期的ＤＩＣ分别占２５、１１、１７例。结果显示，ＡＰＬ合并ＤＩＣ６８％发生于初发期、非Ｍ３期ＡＮＬＬ并ＤＩＣ发生于难治期占６０％，而ＡＬＬ并ＤＩＣ５０％与诱导化疗有关。４０例经全程治疗者，ＤＩＣ治愈８例，其中６例为初发期患者（６／１６）。讨论了ＤＩＣ发生

Clinical Investigation of 53 Cases with Acute Leukemia Associated Disseminated Intravascular Coagulation

This paper presented retrospective investigations of 53 cases with acute leukemia (AL) associated disseminated intravascular coagulation (DIG). Objects included 28 patients with acute promyelocytic leukemia (APL) 15 cases with acute nonlymphoblastic leukemia excluded APL (Non-M3-ANLL) and 10 with acute lym-phoblastic leukemia (ALL). In 53 cases,there were 25,11 and 17 patients with DICwhich occurred respectively at presentation, during and after remission induction,at the refractory stage of the disease. Among patients with APL,DIC was found in 68% at presentation. DIC associated with Non-M3-ANLL was detected in 60% at the refractory stage,and an half ALL-associated DIC related to induction chemotherapy. 8 patients with DIC were cured in all 40 who recieved systemic treatment. DIC at presentation of AL was cured in 6/16. Relationships of DIC with infection, chemotherapy and number of leucocytes were discussed. It conclued that this kind of investigation is useful in prevention and treatment of DIC associated with AL.