高同型半胱氨酸血症与高血压患者左室射血分数的相关性研究

目的探讨高同型半胱氨酸血症（Hhcy）与原发性高血压患者左室射血分数（LVEF）的相关性，评估左室收缩功能受损程度对预测高血压心衰的临床意义。方法选取高血压患者200例，其中非左室肥厚组（NLVH）100例，男性63例，女性37例，年龄（61．2x8．9）岁；左室肥厚组（LVH）100例，男性66例，女性34例，年龄（60．8±9．2）岁；对照组100例，男性65例，女性35例，年龄（60．9±9．5）岁。对所有受试者测定血清同型半胱氨酸（Hcy）水平及行超声心动图检查测量LVEF。结果对照组、NLVH组和LVH组血清Hey水平分别为（9．32±1．91）μmol／L、（20．92±3．28）p,mol／L和（29．60＋3．73）wmol／L，每两组间比较差异均有统计学意义（P〈0．01）。对照组、NLVH组和LVH组LVEF分别为（59．00±4．63）％、（40．70±1．87）％和（39．50±1．46）％，依次显著降低，差异有统计学意义（P〈0．01）。结论Hhcy与LVH呈正相关、与LVEF呈负相关，对预测高血压心衰，减少高血压心力衰竭的发生、发展有一定的临床价值。

Association between hyperhomocysteinemia and left ventricular ejection fraction in patients with hypertension

Objective To investigate the association between hyperhomocysteinemia and left ventricular ejection fraction（LVEF） in patients with hypertension. Methods Two hundred essential hypertensive patients were divided into non-leftventricular hypertrophy （NLVH） group male 63, female 37, average age （61.2±8.9）years, （n=100）] and leftventricular hypertrophy （LVH） group male 66, female 34, average age （60.8±9.2）years, （n= 100）], normal control group male 65, female 35, average age （60.9±9.5）years, （n=100）]. The concentrations of homocysteinemia （Hcy） were detected by enzymatic cycling assay method and the LVEF were examined by echocardiogram. Results Hcy was （9.32±1.91）μmol/L in control group, （20.92±3.28）μmol/L in NLVH group and （29.60±3.73）μmol/L in LVH group. There was great difference in the result of every two groups （P〈0.01）. Control group, NLVH group and LVH group LVEF respectively was （59.00±4.63）%, （40.7.0±1.87）%, （39.50±1.46）%. LVEF was decreased gradually in control group, NLVH group and LVH group. Conclusion Hyperhomocysteinemia is inversely relates with left ventricular ejection and has predictive value in hypertension heart failure.